Sentences with phrase «suppressors when»

The studios use computer - controlled scratch suppressors when preparing old music for release on CDs.

These findings explained why many patients only display partial loss of this tumor suppressor when diagnosed with prostate cancer.

Not exact matches

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

A pre-clinical study of two drugs designed to boost T cell performance, has revealed the agents, when give in combination, may enhance the immune system's ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN.

Collateral lethality occurs when tumor suppressor genes are deleted, a nearly universal occurrence in cancer.

A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.

In their research on young mice, for instance, all the subjects died when they were infected with the Nodamura virus, but when Ding's researchers removed the suppressor protein called B2 from the virus, the infected mice began producing huge armies of the virus - attacking siRNAs and lived, unaffected by the otherwise lethal infection.

If tumors have this PPM1D mutation, they do not have another more common genetic mutation to the TP53 gene, a tumor suppressor that, when defective, is linked to half of all cancers.

«We reasoned that this retained synthetic essential gene might be required for cancer - promoting actions when the cancers lose specific tumor suppressor genes.»

They propose that normal tissue becomes primed for cancer when oncogenes are activated and tumor suppressor genes are silenced or lost, but that cancer develops only when a cell in the tissue reverts to a more primitive, embryonic state and starts dividing.

This phenomenon could result in breakage in the human genome, and when a breakage impacts important genes, such as tumor suppressors, it could lead to cancer development.

In humans, cancer develops when genes that suppress cancer, known as tumor suppressors, are lost and when mutations or genes that promote cancer, known as oncogenes, are gained or activated.

When normal diploid cells lose one or both copies of tumor suppressor genes, cancers can form.

«APL develops when two tumor suppressors fuse together to become an oncogene,» adds co-author Pier Paolo Pandolfi, MD, PhD, Director of the Cancer Center at BIDMC whose own pioneering work revealed the molecular underpinnings of APL and led to its cure.

As a powerful tumor suppressor, p53 turns on genes that either halt cell division to allow time for repair of damaged DNA or, when all rescue attempts prove futile, to prevent cells with genetic defects from dividing, as this would fuel the development of cancer.

When these genes (called tumor suppressor genes) are turned off, MDS cells and cancer cells can grow freely.

Proto - oncogenes consist of a group of genes / proteins that, when expressed, normally encourage cell survival, growth and proliferation, while tumor suppressors perform the opposite task, keeping cells from dividing out of control.

A new study shows that tumor suppressor PTEN helps fight lung infections when attached to a protein that is mutated in cystic fibrosis.

Cancer can also occur when certain normal genes (tumor suppressor genes, for example) are «switched on or off» as a result of environmental epigenetics — influences that occur throughout your life.

When they were treated with the Factor XII suppressors, however, their success in getting out of the maze increased significantly, although it didn't reach the levels of healthy mice.

When tumor suppressor genes work properly, they «slow down cell division,» repair broken DNA, and trigger programmed cell death.

When mutated, or not working properly, cells with abnormal tumor suppressor genes are more likely to grow out of control and lead to the development of cancer.

BRCA1 is a classical tumor suppressor and it is inactivated only when both gene copies / alleles are mutated (one by germ - line mutation and the other by somatic mutation).

When introduced into the MDA - MB - 231 cells, the Δ2A mutant did not induce apoptosis of these cells whereas WT LARP7 readily impaired cell survival, supporting the model that the ability of LARP7 to assemble 7SK snRNP and suppress P - TEFb is necessary for its tumor suppressor potential.

As mentioned in the beginning of this section, the «longevity gene» FoxO3a functions as a suppressor of PCSK9 gene expression when the FoxO3a transcription factor can enter the cell nucleus.

Other cells help turn off the immune attack («suppressor cells») when the fight is over.

The Suppressor no longer reduces the maximum damage of a weapon when equipped.

For instance, a pistol has a higher damage output, albeit making the pistol louder with increased recoil via a magnum upgrade, while an extended magazine doubles the ammunition capacity, alongside a suppressor to silence the pistol when firing which makes it an asset when attempting to stealthily navigate beyond a large group of enemies to not raise the alarm for enemy reinforcements.

For instance, when players within the airborne division level up to rank 1, they will receive an SMG suppressor, while rank 2 will provide the ability to sprint for longer distances; rank 3 allows for faster climbing over obstacles; rank 4 produces a greater sprint speed; alongside a prestige reward for attaining rank 5 including an MP - 40 SMG and energetic basic training resulting in no fall damage and the ability to start sprinting sooner.

The player will be given specific guns at the beginning of each level, but may switch them out with another gun they find.Most guns have attachments, such as suppressors, and heartbeat sensors.The player can also use grenades and flashbangs when faced with a large group of enemies, as well as a knife for close quarters combat.In some levels, the player will be given special equipment, such as night vision goggles, or a laser designator.

Players can even change the attachment in the middle of a match, say for when a suppressor makes more sense than a scope for a particular strategy.

Origin.com: • Access to the open beta in September • Ability to pre-load the game so you're ready to go when the game releases digitally • Back to Karkand DLC • Physical Warfare Pack: 1) the Type 88 light machine gun with bi-pod for deadly firepower and total zone control; 2) the SKS sniper rifle flash suppressor that provides increased stealth abilities for Recon soldiers; and 3) the lethal armor - piercing flechette ammo for the DAO - 12 semi-automatic shotgun that will tear through anything in its path.

It's true to say that nothing gets in your way when you're in the car and when I came across enemies up ahead, I simply used my riot suppressor to knock them out and finished it off with a glide takedown, launching straight from the Batmobile at speed.

We did find an effect of non-anxiety comorbid disorders on externalizing symptoms; non-anxiety comorbidity did have a negative impact on change in externalizing symptoms in anxious children when suppressor effects were taken into account.