Sentences with word «supraphysiological»

Furthermore supraphysiological levels of many acidic hydrolases have no deleterious effect.

Moreover, increasing insulin concentrations could compensate for the reduced GS activity to a certain extent, whereas chronic supraphysiological insulin concentrations induced insulin resistance in GS and glucose transport activity.

In this study, we extended this picture further, since the compensatory effect of hyperinsulinemia on GS in diabetic cultures can be eliminated at supraphysiological insulin concentrations, which induce insulin resistance in diabetic as well as control cultures.

Glutaminase is also allosterically regulated through phosphate, which is required for the formation of the catalytically active tetramer [107], but requires supraphysiological concentrations in vitro.

The enhanced endurance was seen in lab mice with a normal oxygen supply and those with oxygen restrictions which provided significant evidence that GW501516 targets and enhances skeletal muscle endurance and recovery time to a supraphysiological level.