Sentences with phrase «surface cell level»

Not exact matches

As SNX27 plays an important role in shuttling the AMPA - receptor to the brain cell surface, lower levels of SNX27 means fewer receptors are carried to the surface, which consequently interrupts the signal transmission and impairs memory.

«Growing stem cells on synthetic surfaces with different levels of compliance showed that stem cells would become a different cell type depending solely on the mechanical environment they perceive.

Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza virus that enables the virus to enter a human cell and initiate infection.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

Gradual increase of p53 levels activates apoptosis promoting protein Bak on the surface of the mitochondria making these cells vulnerable to death.

It targets the CD52 glycoproteins on the surface of mature immune cells, or lymphocytes, depleting levels of the aggressive T and B cells without affecting other lymphocytes.

On the surface of our numerous star - shaped brain cells called astrocytes, they have found the molecule LRP4 is important in ensuring healthy levels of a brain chemical that enables learning and memory, said Dr. Lin Mei, chairman of the Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia at Augusta University and Georgia Research Alliance Eminent Scholar in Neuroscience.

And in work that has not yet reached the clinic, the Hutch's Leslie Kean and her team built on their discovery that patients with GVHD have high levels of a molecule called OX40 on the surface of T cells.

The findings suggest that reductions in the number of cartilage - producing cells, and greater risk for osteoarthritis, may be driven not just by lower adenosine levels but also by lower levels of the protein on the surface of chondrocytes designed to receive and pass on adenosine's signal.

«By changing the surface properties like the shape of the substrate at the nanoscale level, we tricked the stem cells to behave differently,» explains co-author Dr Julien Gautrot, from QMUL's School of Engineering and Materials Science and the Institute of Bioengineering.

The explanation: Heat caused the HEV cells to express on their surface higher levels of two so - called «homing» molecules, ICAM - 1 and CCL21, which make lymphocytes tightly adhere to the HEV cells.

And even when there was water, he notes, «the hardiest cells we know of could not possibly survive the cosmic radiation levels near the surface.»

As expected, all of the endothelial cell lines showed diminished constitutive expression of E-selectin (data not shown) and VCAM - 1 (Fig. 4C) ⇓ in comparison with surface levels of ICAM - 1 (Fig. 4B) ⇓.

Established cell lines exhibited several inherent endothelial properties, including the expression of constitutive and inducible levels of endothelial cell adhesion molecules E-selectin, intercellular adhesion molecule - 1, and vascular cell adhesion molecule - 1, internalization of acetylated low - density lipoprotein, and formation of loop structures on Matrigel surfaces.

© Wim van Egmond (Photo from Ciliates, used with permission) As the level of oxygen in the atmosphere rose, however, most surface lifeforms on Earth became oxygen breathing, such as these two single - celled protoctists (Euplotes, left, and Stylonychia) which move with hairlike cilia.

High level of cell surface CD4 expression.

Evaluation of conventional and response surface level optimisation of n - dodecane (n - C12) mineralisation by psychrotolerant strains isolated from pristine soil at Southern Victoria Island, Antarctica — Syahir Habib — Microbial Cell Factories

Inventors at MUSC have identified a unique human CD4 + T cell population that expresses high levels of surface CD26, termed CD26high T cells, which mediate durable antitumor immunity in vivo, and have immediate clinical relevance for designing new vaccines and cellular therapies.

A library of recombinant P. falciparum secreted and cell surface proteins was expanded by 20 additional proteins, which were shown to express at usable levels and contain conformational epitopes.

(B) Percent of sorted single HES3 cells in (A) expressing stem or lineage markers according to level of surface marker expression.

People who had a better antibody response to the vaccine after 28 days had higher levels of HLA - DR (a cell surface protein which is a marker for immune stimulation) on a specialised type of dendritic cell.

Our laboratory used two monoclonal antibodies, GCTM - 2 and TG30, recognizing the cell surface proteoglycan characteristic of primate ES cells and CD9 respectively, to fractionate human ES cell populations into four compartments according to their relative levels of expression of both markers [14].

This gradient of surface antigen expression was paralleled by a gradient in expression of pluripotency genes, with highest levels of genes like Oct - 4 found in the population of cells with the highest level of antigen expression.

A. Fractionation of HES 3 or H9 cells by flow cytometry according to the levels of expression of cell surface markers (GCTM - 2, pericellular matrix proteoglycan, and CD9).

Levels of expression of pluripotency genes declined in parallel with the levels of stem cell surface antLevels of expression of pluripotency genes declined in parallel with the levels of stem cell surface antlevels of stem cell surface antigens.

Haihui Lu, Ph.D., a CRI fellow at the Whitehead Institute for Biomedical Research, has identified a surface marker that distinguishes a population of breast cancer cells that are more prone to metastasis and demonstrate higher levels of «stemness,» the ability to seed other tumors.

This loss of binding is often accompanied by a loss of ability to express (Barnwell et al. 1983; Handunetti et al. 1987; Gilks et al. 1990)-- or a major alteration in the level of expression of (David et al. 1983; Fandeur et al. 1995)-- the highly variable and clonally variant switching parasite antigens on the surface of the red cell known to be important for the maintenance of long - term chronic infections (Brown and Brown 1965).

This product uses the technology of fruit base cells to help nurture and feed the skin at a much deeper level and leave it smoother on the surface.

Better blood circulation means more toxins flow from the cellular level to the skin's surface to improve cell health, aid in muscle recovery and strengthen the immune system.

This unique patented combination of ingredients is designed to stimulate enzymes that help break the bonds binding dead skin cells to skin's surface, to evenly exfoliate skin while maintaining the skin's moisture levels

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In humans, L - carnitine helps to increase the growth of muscle cell fibers by increasing energy production within cells and by increasing the number of androgen receptor sites on the muscle cell surface, which in turn increases the level of circulating testosterone.