Sentences with phrase «surrounding cells and tissues»

To fulfil the promise of stem cell therapy, it is important to discover the function of the respective stem cells and understand how they interact with their environment, that is, the surrounding cells and tissues,» explains Prof. Lohmann, who heads the Developmental Biology research group at the Centre for Organismal Studies (COS).

As a result of this, their bodies will release a lot of free radicals that if not eliminated, will cause damage to the surrounding cells and tissues.

In addition, the polymer - based material, called Parylene C, is less invasive and damaging to surrounding cells and tissue than previous microelectrode arrays comprised of silicon or microwires.

Not exact matches

But in the following hours and days, the body's self - defense mechanisms backfire: White blood cells come in to clean up dead tissue, which causes massive inflammation, which in turn triggers healthy cells in the surrounding tissue to self - destruct in a process called apoptosis.

Such was the comfortable vista which, less than a century ago, began abruptly to change beneath our gaze, something in the fashion of those organic tissues in the living body which, after long remaining harmless and dormant, their cells apparently indistinguishable from those of the surrounding tissue, suddenly burst into dangerous growth.

Despite a tremendous amount of scientific study, many outstanding mysteries still surround the way in which cells in living tissue respond to and repair physical damage.

Understanding how margin length decreases from surgery to pathology — because of how the removed tissue shrinks and tumor cells invade surrounding tissues — can lead to better surgical margin planning and in turn a better prognosis, said corresponding author Milan Milovancev, a board - certified veterinary surgeon at OSU's College of Veterinary Medicine.

The term «in situ» means that the cancerous cells are contained within the breast's milk ducts and have not invaded the surrounding tissue.

This early stage research will explore how the virus targets stem cells and provide the starting point to develop new treatments that seek out the tumour and spare the surrounding healthy brain tissue.

The immune cells appear to travel to the lens via a web of ligaments that suspends the lens and connects it to the surrounding muscle tissue called the ciliary body, rich with immune - cell - carrying blood vessels.

Many studies have shown that stiffness of the extracellular matrix, the fibrous network of collagen that surrounds cells, promotes cellular mobility; cells can get a better grip on stiffer surfaces and thus invade neighboring tissue.

By carefully controlling the composition of the droplets and the strength of the magnetic field, the forces applied by the droplet can be controlled, and the response of the surrounding tissue reveals its mechanical characteristics as well as the cues that cells are exposed to as the tissue grows.

The buildup of twisted tau deposits also destroys surrounding nerve cells and eventually wastes away vast swaths of brain tissue.

«But in many of these cases the implant was removed without testing the surrounding fluid and tissue for lymphoma cells, so it's difficult to definitively correlate the two.»

FAT AS A FIXER Adipose tissue, a collection of fat - storing cells (red) surrounded by connective tissue (yellow), has its own supply of blood and immune cells.

Achieving that could have a big medical payoff, but to make it work, we needed to understand the fundamental interactions between cardiac valve cells and the tissue matrix surrounding them.

In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissue.

Abnormal and uncontrolled production of this class of proteins, known as transcription factors, allow for cells to bypass growth control mechanisms and to develop characteristics necessary for invading surrounding tissues.

«We learned the damaged cells send signals to the surrounding, unaffected cells and likely modify the tissues» microenvironments.

But working with human smooth muscle cells isolated and grown from the healthy parts of airway tissue surrounding excised tumors, Benjamin Kalbe and his colleagues applied a large number of odor molecules and watched two of them activate the muscle cells.

Cancer begins with a series of genetic changes that prompt a group of cells to overreplicate and then invade surrounding tissue, the point at which true malignancy begins.

«The Achilles heel of pancreatic cancer cells is their need for the surrounding tissue to structure them and help them to grow and move,» says Timpson.

The corneal stem cells, like many other cells, have sensors that measure the stiffness of surrounding tissues and allow the cells to adapt accordingly.

Instead, tumors should be considered complex tissues in which the cancer cells communicate with the surrounding cellular microenvironment and evolve traits that promote their own survival.

The result — the second such finding in the past year — suggests that similar cells from human testicles might have similar powers, paving the way to creating replacement tissue for men who have suffered damage from heart attacks or other injuries and avoiding some of the controversy surrounding embryonic stem cells (ESC).

The hepatocytes are first patterned onto surfaces dotted with tiny spots of collagen, and then surrounded by supportive tissue made up of stromal cells, which act as connective tissue and support the hepatocytes in carrying out their liver functions.

Once inside, researchers found that the antibodies zeroed in on their targets — viral antigens — and the radioisotopes destroyed nearby cancer cells without damaging surrounding healthy tissue.

Instead, tumors should be considered as complex tissues in which the cancer cells communicate directly and indirectly with the surrounding cellular microenvironment and evolve traits that promote their own survival.

This activation causes additional stress which keeps the macrophages «turned on» in a cycle that amplifies and further damages the cells and surrounding tissues.

For several years, the research team from the Turku Centre for Biotechnology lead by Professor Johanna Ivaska has focused their efforts on understanding how cancer cells move and invade surrounding tissue.

Even though the invasive cells have an advantage because of their ability to invade surrounding tissues, that invasive nature also has its drawbacks: increased susceptibility to changes in limited resources and their environment.

This process requires a fundamental change in the character of cells within the primary tumor, insofar as members of a localized cell mass must be converted into actively migrating cells that invade into the surrounding tissue and blood vessels, and finally settle in distant tissues.

The two sperm cells independently fertilize the egg cell and the central cell to produce the embryo and the endosperm (a tissue that surrounds and nourishes the embryo), respectively, which eventually develops into a seed.

When the researchers injected MVs directly into the amniotic sac (the fluid - filled cavity surrounding the embryo) of pregnant mice, they observed that 24 hours later the tissue of the interface between mother and fetus was severely disrupted, with broken collagen fibers, hallmarks of inflammation, and signs of extensive cell death.

To test the theory, Arlinghaus and colleagues first demonstrated that BCR - ABL positive cells expressed 24p3 and secreted it into the surrounding tissue, causing cell death.

Phages, shown here surrounding and attacking a bacterial cell, are part of a newly discovered type of immunity that protects mucus - covered human tissue from bacterial infection.

Heparanase is a long - studied protein in human tissues involved in breaking down the complex sugars of the «extracellular matrix» — the material surrounding cells that provides structure and stability.

«Due to the nature of how a cell nestles among its immediate neighbors, a scientist can now look at cell shapes and make a reasonable guess as to why, and how fast, those cells will migrate, remodel, or invade surrounding tissues.»

The finding, reported by researchers at Harvard T.H. Chan School of Public Health, Northeastern University, and MIT, provides insights into organ formation in an embryo, healing of a wound, and even invasion of cells into surrounding tissue, as occurs in cancer.

The surrounding material, especially the periosteum and the growth protein, helped to cue the stem cells to produce bone tissue.

The result are cancer cells that are capable, from the very start, to invade surrounding tissue and spread metastases.»

Pericytes and adventitial reticular cells (ARCs) are perivascular cells, found in many tissues, which are recruited to blood - vessel walls from the surrounding tissue during organ development and growth.

When they infiltrate a plant, they release an enzyme that causes the surrounding tissues to swell into giant cells, draining the plant's strength and leading to symptoms such as stunted growth and wilting.

Multipotent stem cells have been found in the chorion, placenta, amnion, amniotic fluid, and in the tissue surrounding the umbilical cord vessels, i.e., Wharton's jelly, and in the umbilical cord itself.

Often when a migratory cell moves, it is responding to a chemical stimuli — a gradient of molecules in the tissue or bloodstream surrounding the cell that it can detect and follow.

Affected cells signal to surrounding unaffected cells and likely alter the tissue environment.

Scientists from the LoGrasso lab have been able to show in animal models that inhibiting a specific enzyme protects heart cells and surrounding tissue against serious damage from heart attacks.

«Instead, some cancer cells seem to reactivate and corrupt programs that govern fetal tissue stem cell function, including programs from their neighboring cells that constitute the surrounding fetal stem cell landscape, or microenvironment.»

Furthermore, de-regulation of their functions is deleterious to tissue architecture and can result in the sorting of somatic rounded clones minimizing their contact with surrounding wild - type (wt) cells.

By analyzing the evolution over time of ft mutant cells and clones, we show that ft clones reduce their cell - cell contacts with the surrounding wt tissue in the absence of concomitant cell divisions and over-proliferation.