Instead of activating a small sphere
of surrounding neurons as expected, the electrodes caused sparse strings of neurons to fire across the brain.
That translates to an impaired ability for neurons to receive whatever
signals surrounding neurons are trying to send and mice displaying schizophrenia - like behavioral deficits such as impaired cognition and sense of direction.
Another hypothesis is that instead of secreting chemicals, astrocytes exert their effects by controlling the uptake of neurotransmitters from the
space surrounding neurons, thereby affecting neuron activity indirectly.
However, research published in Nature Biomedical Engineering reveals that it may also be important to target the supportive glial
cells surrounding the neurons.
Alzheimer's disease, which is characterized by a loss in motor, psychological, and cognitive function, is attributed to the build up of beta - amyloid
plaque surrounding neurons.
A companion set of miniature injectors could administer compounds to inhibit the formation of scar tissue or to stimulate the activity
of surrounding neurons.
Neuroscientists have long believed that scar tissue formed by glial cells — the cells that
surround neurons in the central nervous system — impedes damaged nerve cells from regrowing after a brain or spinal cord injury.
The surrounding neurons that were there all along, however, had sprouted a denser set of connections with other cells, presumably allowing for better transmission of information and recovery of function.
However, in the mice treated with the APOE compound, each plaque triggered only about half as much damage to
the surrounding neurons, suggesting that even a late start could reduce the harm posed by amyloid beta.
Even more surprising, these cells appear to stimulate axon myelination in
the surrounding neurons.»
He and his team could then activate or deactivate these subiculum neurons with piped - in laser light, leaving
the surrounding neurons unaffected.
They provide a source of nutrients, maintain the equilibrium in the fluids that
surround the neurons, participate in neural repair, and take up and release brain messenger - molecules.
If he can determine how to speed up engulfment of dead tumor cells from brain tissue, it is his hope to reduce the harmful inflammation that causes death of
surrounding neurons.