Sentences with phrase «susceptibility genes for»

GENIC has completed (or has ongoing) a series of studies to examine the interaction between environmental risk factors and susceptibility genes for non-Hodgkin lymphoma, melanoma, and multiple myeloma, as well as breast, ovarian, and prostate cancers.

Deeper analyses, revealed that the RNA expression pattern of a rare variant of the NCAN gene was highly correlated with that of the previously suggested susceptibility genes for developmental dyslexia.

Susceptibility genes for diabetes may be involved in several different metabolic pathways in the body, including storage and release of fat for energy.

Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia.

September 26, 2000 Researchers discover major diabetes susceptibility gene For the first time, a genome - wide approach has identified a major susceptibility gene for a common, genetically complex disorder — type 2 diabetes in Mexican Americans.

The 48 - letter polymorphism has been the focus of virtually all ADHD association studies in recent years, and those results are the reason DRD4 is generally considered to be a susceptibility gene for ADHD.

A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting.

A paper describing the discovery, entitled «A major susceptibility gene for asthma maps to chromosome 14q24,» has been published in the online edition of the American Journal of Human Genetics at www.ajhg.org.

A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting American Journal of Human Genetics 2003 Jan; 72 (1): 125 - 31.

A susceptibility gene for late - onset idiopathic Parkinson's disease Annals of Neurology 2002 Nov; 52 (5): 549 - 55.

Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12.

Not exact matches

There, he started a medical school, led worldwide clinical trials to advance care for heart disease, and spearheaded the discovery of genes that increase susceptibility for heart attacks.

One of my nightmares is that a woman learns that she doesn't have the high - risk form of the gene for breast cancer susceptibility, so she decides she no longer needs to get mammograms.

The retinoblastoma (RB) susceptibility gene was the first gatekeeper gene discovered for cancer.

He was also missing the Alzheimer's susceptibility allele apo, a well - established variant of a gene for apolipoprotein E carried by approximately two out of three patients.

As it is well known that hypertension is a complex, multifactorial, quantitative trait under a polygenic control, 30 % to 50 % of the variation in blood pressure between individuals is attributed to genetic factors, and the genes responsible for susceptibility and blood pressure variation are mostly unknown.

One study even identified two genes in which particular variants can slow the onset of AIDS, demonstrating the potential of this approach for understanding why people vary in their susceptibility to infectious diseases.

In discussing why genetics researchers are not finding genes for disease susceptibility, the «dark matter» of genetics, Peter Aldhous and...

Geneticists have so far concentrated on genes that are linked to disease: first the simple but rare inherited diseases like cystic fibrosis (the gene for which is on chromosome 7) or Huntington's (chromosome 4), then the environmental diseases for which different people inherit different susceptibilities, such as Alzheimer's (chromosome 19) or breast cancer (chromosomes 13 and 17).

For the more common form of late onset AD (LOAD), ApoE is the only clearly established susceptibility gene.

«Isolating the genes that determine susceptibility could lead to developing immunities for different varietals and other crop plants and may contribute to general scientific knowledge of the grapevine, which has not been studied to the extent of other plants.»

«We hope that our findings will foster development of a personalized strategy for the prevention and treatment of multiple sclerosis, one that takes into account the gender - specific contribution of galanin gene variants to susceptibility and disease progression,» said Dr. Victoria Lioudyno, lead author of the study.

About 20 % of breast cancers are inherited, but the known susceptibility genes account for just a small portion of these breast tumors.

Because susceptibility genes can help predict cancer and unravel its course, researchers are constantly searching for new ones.

Fanconi anemia and breast cancer are like «two facets of the same disease,» he says, predicting that the search for cancer susceptibility genes will now turn to Fanconi anemia.

FRY could potentially be used as a platform to develop cancer gene - based susceptibility tests, for disease progression and for tumor grading.

Are there genes for susceptibility to disease?

In collaboration with deCODE Genetics, susceptibility loci for T2D were identified in three genes (TCF7L2, CDKAL1, and TCF2 [HNF1β]-RRB-.

Our findings provide mechanistic underpinnings for the previous implication of Del - 1 as a candidate MS susceptibility gene and suggest that Del -1-centered therapeutic approaches may be beneficial in neuroinflammatory and demyelinating disorders.

The discovery should speed the search for additional genes that increase susceptibility to autism and enhance understanding of this complex disorder.

«But this is the first time on a large scale that we've been able to pinpoint gene culprits or even the actual mutations responsible for cancer susceptibility.»

Genetic susceptibility to comorbid psychiatric phenotypes in a panel of mice deficient for the human type 2 diabetes gene TCF7L2.

Another group investigated CD8 + T cells, and found that babies had epigenetic and gene expression profiles that resembled those of innate immune cells, which «may provide a partial explanation for infants» higher susceptibility to infectious pathogens,» GenomeWeb reported.

For melanoma it is easiest to group susceptibility genes into rare high penetrance genes and more common lower penetrance genes but the truth is that this distinction is not absolute.

how environmental susceptibility genes — issues with detoxing toxins — make it difficult for your brain or gut to function properly

It is well known that purebred dog breeds are associated with differing susceptibility to specific malignancies, suggesting that selected breeds of dog are inheriting «at risk» alleles for very few genes, perhaps even a single gene, with a profound effect.

Samples from canine patients will not only allow the researchers to identify genes responsible for breed - specific susceptibilities (such as hemangiosarcoma in Clumber spaniels and osteosarcoma in Greyhounds), but also to translate these discoveries into new and more precise diagnostics and therapeutics for both canine and human cancer patients.

For single - gene DNA tests to be fully effective in reducing or eliminating inherited disorders, the tests must not be based on any preliminary or assumed relationship, and we must understand the full biology between susceptibility and resulting development of disease.

Although canine models of various cancers garner increasing interest as in vitro systems suitable for studies of basic biology and drug development, the fact that breed specificity is observed for many types of cancer has excited geneticists who are anxious to localize susceptibility genes that have proved intractable in human families and populations.

Support for the association between the rare functional variant I425V of the serotonin transporter gene and susceptibility to obsessive compulsive disorder

Gene and environment interaction: Is the differential susceptibility hypothesis relevant for obesity?.

Social environmental variation, plasticity genes, and aggression: Evidence for the differential susceptibility hypothesis