Sentences with phrase «sustained on the global level»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«It was remarkable how we were able to examine this question on a global level, thanks to the sustained efforts of many programs and individuals.»

«Warming greater than 2 degrees Celsius above 19th - century levels is projected to be disruptive, reducing global agricultural productivity, causing widespread loss of biodiversity and — if sustained over centuries — melting much of the Greenland ice sheet with ensuing rise in sea levels of several meters,» the AGU declares in its first statement in four years on «Human Impacts on Climate.»

On the other hand, while sustained high oil prices could provide climate change mitigation efforts a mild boost, the study concludes that such market developments would be no substitute for concerted global policy to limit climate change to below 2 °C above preindustrial levels.

With humanity's ecological footprint of 2.7 global hectares (gha) per person means to say that to sustain the current population on Earth of 7 billion people would take 18.9 billion gha (2.7 gha x 7 billion people) which is higher than the 13.4 billion global hectares (gha) of biologically productive land and water on Earth, a fact that indicates that already exceeded the regenerative capacity of the planet in the average level of current world consumption.

Since global equity markets hit a high on 25 January 2018, they have struggled to sustain that level, at the end of April 2018, the market is still down -6 % since those highs.

Panelists will discuss and assess the current political landscape on global, national and regional levels and share «tools» regarding art production, political action and sustaining our communities and ourselves.

The long - term sea level rise will depend critically on the cumulative carbon emission pathway humans follow, which determines the sustained global warming that can be maintained for centuries to millennia.

Communities will become self sustaining, interrelated in a sustainable manner that organically is unified on a global level.

Estimates of CO2 level and average global temperature trajectory (no sustained temperature change) for the last 500 million years is evidence CO2 has no effect on climate.

Carbon trading is not sufficient on its own to achieve the Paris climate goals but equally we will not slash emissions to the level required under Paris without a much more concerted and sustained global take - up of carbon pricing.