Sentences with phrase «sustained over a number»

Not exact matches

Moody's Investor Services says spending pressure will challenge the province's ability to «sustain balanced fiscal results» over a number of years.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Engineering construction activity has nearly doubled over the past two years and this upswing is likely to be sustained in the period ahead, with a number of significant road and mining - related projects scheduled for commencement in 2004 (Graph 41).

Despite the recent deferral and cancellation of a number of projects, the outlook for engineering construction activity remains strong, with the large amount of infrastructure and resource - related work still to be completed likely to sustain growth in activity over most of 2004.

Both Mouton Cadet and the America's Cup are world - leading brands which have been built over many years through the dedication of committed teams who pull together to achieve and sustain the number one position.»

Over that timeframe, it has sustained thousands of generations of people, cumulatively numbering in the tens or even hundreds of millions.

Despite contributing sustained excellence over a number of seasons at Everton, the aura around...

Protecting players from increased risk of traumatic brain injury by teaching them «heads up» tackling and blocking, equipping them with properly fitted helmets, strengthening their necks to better withstand the forces that cause concussion, and by limiting the number of hits they sustain over the course of a season and career;

In the newest generation of parents there are increasing numbers of higher earning mothers, and fathers willing to take on more of the care of children; in many couples both partners work full - time — but the childcare costs which hamper the poorest in entering the workforce also lead to difficulties for parents sustaining employment over time.

Publication of the Purdue study sent shock - waves reverberating through the football world, with the findings cited by concussion experts calling on youth sports organizations to take more aggressive action to minimize exposure to RHI, including sub-concussive blows, by changing the way contact and collision sports are played and practiced, and reducing the amount of brain trauma a child incurs by limiting the number of hits they sustain in a sports season, over the course of a year, and during a career.

Finding a way to reconcile two competing demands - minimizing contact in practice in order to reduce the number of concussions sustained and the number of hits players sustain over the course of a week and a season that emerging science, now more than ever, suggests may have a deleterious cumulative effect [26] on a player's cognitive function over the long term, while at the same time maximizing the amount of time in practice learning how to tackle and block without head - to - head contact - time that is needed to maximize the protective effect of proper tackling on the number of head - to - head hits players sustain in game action, which can not only result in concussion, but catastrophic neck and spine injuries - is challenging, but clearly not impossible.

At least one person was feared dead yesterday while over 22 others sustained various degrees of injury when masquerades in their numbers invaded the Holy Ghost...

Senator Ojodu wondered why there was fear and misgivings over calls for State Police noting that with the magnitude of personnel needed and resources to sustain the required number of Policemen for the country, State Policing was the way to go.

The original, randomized, open label study, which enrolled 20 outpatient men with cirrhosis and recurrent HE receiving standard - of - care (SOC) treatment, had previously reported that a single FMT enema after antibiotic pretreatment improved cognitive function at Day 20 and reduced HE episodes and hospitalizations over the following 5 months compared with SOC.1 The long - term outcomes of this study, which were presented today at The International Liver Congress ™ 2018 in Paris, France, demonstrated sustained and statistically significant reductions in the number of HE episodes and hospitalizations as well as improvements in cognitive function over 1 year in the men who received FMT compared with the control group.

The sheer number of variables is evidence that any response by school systems must be multidimensional, targeted at multiple levels of the system, and sustained over time.

It means they need lots of focused experiences with numbers and ways of deconstructing them, and that they need these experiences repeatedly and over a sustained period of time.

She added that the impressive sales numbers for the first six books of The Godling Chronicles series in both audiobook and ebook formats, and their sustained sales over the past four years, convinced Audible that even a six - figure advance was not much of a risk.

Over the coming months, we will continue to reach out to the community and businesses asking for everyone's help so that we can sustain our live release numbers of at least 90 % (and hopefully more) into the future.

However, once the brigade has retreated, Plume will be on her own against an overwhelming number of enemies or a large powerful monster so you must make sure that you don't sustain too much damage or its game over.

steven, in round numbers, you need 1 W / m2 sustained over the past century to account for how much the ocean volume has warmed.

The Great Lakes are the world's largest group of freshwater bodies, hosting a large number of species within their waters and on their shores, but also sustaining life over large areas of North - America thanks to their tributaries» impact on land ecosystems.

Our client sustained a number of injuries in the accident, the most serious of which was to his right wrist, described by our orthopedic expert as «chronic and static with a very high likelihood of deteriorating over time.»

This does not mean the lawyer or law firm has won every case, but rather has sustained a successful personal injury practice over a number of years.

I guess children who have a number of risk factors, and particularly if those are either severe or sustained over time, are much more at risk of poor developmental outcomes than those children who might have exposure to one or two risks, which are either short or intermittent, but there's not that sense of cumulative risk.

A study of individual cognitive therapy for bipolar disorder showed positive outcomes at 1 - year follow - up, but the benefits were reduced over time, suggesting the need for booster sessions to sustain the gains.19 As with many forms of therapy, CBT has been found to be more successful in reducing relapse in the depressive pole compared with the manic pole.30 A large randomised trial of CBT showed no difference between CBT and treatment as usual, when all participants were included in the analyses.31 However, results of a post-hoc analysis suggested that CBT was effective for participants who reported fewer than 12 prior episodes of illness and were not acutely unwell when therapy began; numbers of episodes of mania rather than depression seemed to predict treatment response.32 Such data can help guide the clinical application of CBT for bipolar patients.

Bilingual schools have been reducing in number over time because of the lack of fully trained teachers and the lack of capacity to sustain these resource - intensive programs.

Ochsner feels that the numbers probably won't sustain, and that the 40 percent increase in inventory over the last year will be helpful.