Sentences with phrase «sustained over time at»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«Leveling up your finances — and adding commas — will likely be a result of consistent, positive habits sustained over a long period of time,» says Jason Kirsch, Certified Financial Planner at Marcum Financial Services LLP in Chicago.

«Leveling up your finances — and adding commas — will likely be a result of consistent, positive habits sustained over a long period of time,» says Jason Kirsch, Certified Financial Planner at

He concluded that, based on the current stated amount of underfunding at every big pension fund, if the Dow / SPX declined 10 % or more over a sustained period of time — where «sustained period» is defined as 3 - 4 month — every public pension fund in the country would collapse.

As we have seen time and again, the flexible workspace market has experienced incredible growth and is sustaining that growth across the world; Savills found that UK serviced office take - up increased by more than 150 % in 2017, while CBRE discovered that the flexible office market has been growing at an average of 13 % per annum over the last decade.

Food is not fixed in time, yet we have been poor managers of our resources over the years as human civilization has progressed and today stand at a situation where sustaining our biggest source of energy has transformed into our biggest problem coupled with environmental degradation.

It will set you up in the morning with a tasty savoury flavour and get your body burning fat and protein over a sustained period of time rather than an insulin - spiking quick release carbohydrate or sugary breakfast likely to have you starving for lunch... or even worse, craving sugary things at 11 am!

According to The Sun, the 24 - year - old is «in a race against time to be fit» having sustained a hamstring injury last weekend in the win over Liverpool, and so Tottenham will have to carefully monitor him in the next 24 hours to determine whether or not he can feature against the Red Devils at Old Trafford.

The Frenchman has been at the club for over 20 years and led us through some amazing times, but having endured tough financial times while the new stadium was being built, they have failed to sustain a serious title challenge for a while now.

The Gunners have a daunting opening Champions League game away at Borussia Dortmund in eight days time, but we have been given a boost by the fact that Marco Reus has sustained an ankle injury in Germany's 2 - 1 win over Scotland last night, and is now likely to miss the match against Arsenal.

Financial Fair Play (FFP) regulations were introduced in 2012 to «reduce the levels of losses being incurred at some clubs and, over time, establish a league of financially self - sustaining professional football clubs».

«Gylfi Sigurdsson will see a specialist this evening to determine a time frame for recovery from the knee injury he sustained in Saturday's Premier League win over Brighton at Goodison Park,» Everton's statement said.

Having worked with thousands of women over the past two decades, best - selling author Samantha Ettus shares the secrets for how you can sustain a thriving personal and professional life at the same time.

Finding a way to reconcile two competing demands - minimizing contact in practice in order to reduce the number of concussions sustained and the number of hits players sustain over the course of a week and a season that emerging science, now more than ever, suggests may have a deleterious cumulative effect [26] on a player's cognitive function over the long term, while at the same time maximizing the amount of time in practice learning how to tackle and block without head - to - head contact - time that is needed to maximize the protective effect of proper tackling on the number of head - to - head hits players sustain in game action, which can not only result in concussion, but catastrophic neck and spine injuries - is challenging, but clearly not impossible.

I hope those Fabian members and other Next Left readers who are not already part of the Avaaz network will look at getting involved in this campaign and the other initiatives and campaigns: the case for sustained and positive civic pressure over time is massively important in between the big summits which hit the headlines.

In some cases, at risk populations live in environments that are remote and as a result it is expensive to collect data over a sustained period of time.

«Future studies will look at which patients with MS might respond most to cognitive remediation, and whether these improvements can be enhanced or sustained over longer periods of time.»

But the study looked at departures from average conditions over shorter time periods, and may not be a good indicator of how people will respond to sustained warming.

«Growth in employment for both people with and without disabilities has been pretty positive over the past few months, although moreso for people with disabilities, which is the first time I have ever seen this occur in a sustained fashion,» said Andrew J. Houtenville, Ph.D., associate professor of economics and research director at UNH - IOD.

Female athletes are at risk for common nutrient deficiencies, such as low protein, low iron, low calcium, and low vitamin D. (3) When active women don't eat enough nutrients, or they are poorly absorbed due to increased intestinal permeability (leaky gut), SIBO, SIFO, or other causes of intestinal epithelial inflammation, they are not nourished enough to sustain intense exercise over time.

This is the hurdle at which most of your competitors will fall because successful site promotion and business promotion requires patience and sustained effort over a long period of time.

And while Landline portrays characters grappling in their own ways with the age - old institution of marriage and the expectations of monogamy it creates, Robespierre isn't cynical about romantic relationships, recognizing the need for constant companionship, while acknowledging the at - times - agonizing difficulties in sustaining them over a long period of time.

At over two hours, there is a little too much time and not enough plot to sustain a sense of momentum.

«The retention rate at Bathurst has certainly improved, due to a sustained effort over time.»

If you don't have a mechanism to renew your enthusiasm or at least sustain it and keep it going, then over time your organisational capacity will diminish — and the same is true for principals and teachers personal capacity to keep pace with educational change.

Wilbur Rich, a professor emeritus of political science at Wellesley College in Massachusetts, said he wouldn't call any of the experiments with mayoral control a success - not until the gains are larger or sustained over a longer time.

All of these programs are research - tested and have demonstrated sustained effectiveness over time and at significant scale.

Her doctoral work at Stanford University focused on the challenges and possibilities of sustaining reform over time, as well as the role of professional learning communities and evidence use in driving equitable practices.

As Dr. Kristin Cuilla, Senior Director of Partnerships and Communication at the NTN shared, instead of parachuting teachers in, the NTN works actively with people who have roots in the community, paving the way for innovative practices to be sustained over time.

The sheer number of variables is evidence that any response by school systems must be multidimensional, targeted at multiple levels of the system, and sustained over time.

Over time, we support our teacher leaders in assuming responsibility for leading and sustaining the collaborative inquiry communities we have established at their sites, with the aim of teacher leaders becoming independent drivers of the work by Year 3 and beyond.

As much as the wife and I love NPR (seriously... we listen to NPR instead of watching TV, or we'll sit around and play video games while listening, and there have been countless times we've sat in the car in the garage or at the store for another ten minutes just to hear the end of whatever story was on at the time), our time as sustaining members is over.

Prudent investors should also be paying attention to dividend payout ratios (DPRs), which describe the degree to which companies can sustain payouts at the current level of dividends over time.

This turns the dash into more of a strategically employed sprint, allowing Gunvolt greater speed sustained over longer distances, at the extremely high cost of manoeuvrability and a further reduction in reaction time.

It's smarter to increase your investment gradually, and to develop momentum over time, than it is to come out of the gates at a pace that's difficult to sustain.

Moderated by Sharon Louden, Artist and Editor Panelists include: Sean Mellyn and Jennifer Dalton, Artists and Contributors to «Living and Sustaining a Creative Life» Christian Viveros - Faune, Writer, Curator and Art Critic for the Village Voice Paddy Johnson, is the founding Editor of Art F City and writes a column on art and Internet for artnet news At a time when art is increasingly viewed as a commodity and art - school graduates feel that gallery representation is imperative for making a living and a career, it is more important than ever to show the reality of how an artist sustains a creative practice over time.

It seems hardly any country in the world has moved the decarbonization rate upwards by 1.3 % over a sustained period of time, and the one major economy that may have done so (the UK) has gone through a coal - to - gas transition that can't be repeated, while de-industrializing at the same time.

I think you've answered your own question in part — even PDO does not act at the time scales necessary to produce sustained increasing global temperature over decades.

However, we again found that familiarity impacted the efficacy of the correction: People were better at sustaining their belief over time if they were middle aged participants under the age of 65, in comparison to those over the age of 65.

Attaching themselves to black smokers, the worms have been found to thrive at sustained temperatures of from 45 to 60 °C (113 to 140 °F) and even 105 °C (221 °F) for a short time, [3] making the Pompeii worm the most heat - tolerant complex animal known to science after the tardigrades (or water bears), which are able to survive temperatures over 150 °C.

However, Poole provided the important caveat that laptops are better at delivering sustained performance over a longer period of time, as opposed to the shorter max burst performance that benchmarks like Geekbench 4 are designed to measure.

Required Qualifications * Must be at least 16 years of age * Licensure requirements vary by state * Attention and Focus o The ability to concentrate on a task over a period of time without being distracted * Customer Service Orientation o Actively look for ways to help people, and do so in a friendly manner o Notice and understand customers» reactions, and respond appropriately * Communication Skills o Use and understand verbal and written communication to interact with customers and colleagues o Actively listening by giving full attention to what others are saying, taking time to understand the points being made, asking questions as appropriate, and not interrupting at inappropriate times * Mathematical Reasoning o The ability to use math to solve a problem, such as calculating day's supply of a prescription * Problem Resolution o Is able to judge when something is wrong or is likely to go wrong; recognizing there is a problem o Choosing the best course of action when faced with a complex situation with several available options PHYSICAL DEMANDS: * Remaining upright on the feet, particularly for sustained periods of time * Moving about on foot to accomplish tasks, particularly for moving from one work area to another * Picking, pinching, typing or otherwise working primarily with fingers rather than whole hand or arm * Extending hand (s) and arm (s) in any direction * Bending body downward and forward by bending spine at the waist * Stooping to a considerable degree and requiring full use of the lower extremities and back muscles * Expressing or exchanging ideas by means of spoken word; those activities where detailed or important spoken instructions must be conveyed accurately * Perceiving the nature of sounds at normal speaking levels with or without correction, and having the ability to receive detailed information through oral communication * Visual Acuity: o The worker is required to have close visual acuity to perform activities such as: transcribing, viewing a computer terminal, reading, visual inspection involving small parts * Occasional lifting of up to 30 lbs; exerting up to 30 lbs of force occasionally and / or up to 10 lbs of force frequently, and / or a negligible amount of force constantly to move objects Preferred Qualifications * Previous experience in a pharmacy, retail, medical, or customer service setting * Previous experience as a Pharmacy Technician * PTCB National Certification Education * High School diploma or equivalent (preferred) Business Overview CVS Health, through our unmatched breadth of service offerings, is transforming the delivery of health care services in the U.S..

I guess children who have a number of risk factors, and particularly if those are either severe or sustained over time, are much more at risk of poor developmental outcomes than those children who might have exposure to one or two risks, which are either short or intermittent, but there's not that sense of cumulative risk.

A study of individual cognitive therapy for bipolar disorder showed positive outcomes at 1 - year follow - up, but the benefits were reduced over time, suggesting the need for booster sessions to sustain the gains.19 As with many forms of therapy, CBT has been found to be more successful in reducing relapse in the depressive pole compared with the manic pole.30 A large randomised trial of CBT showed no difference between CBT and treatment as usual, when all participants were included in the analyses.31 However, results of a post-hoc analysis suggested that CBT was effective for participants who reported fewer than 12 prior episodes of illness and were not acutely unwell when therapy began; numbers of episodes of mania rather than depression seemed to predict treatment response.32 Such data can help guide the clinical application of CBT for bipolar patients.

My personal investing strategy is to set up a property so that it can sustain rent decreases of at least 25 %, and vacancies of at least 4 months at the onset, and build even further reserves over time.