Entire
swaths of human genetic variation, however, remain to be understood and we should push toward the routine de novo assembly of genomes as opposed to simply aligning to a reference for variant discovery.
Not exact matches
The work on gorilla and other
human genomes clearly demonstrates that large
swathes of genetic variation can't be understood with the short sequence - read approaches.
These deep catalogs
of human genetic variation should make it possible to discount an ever - larger -
swath of rare but neutral variants.