It turns out that saccharin doesn't just
activate sweet taste receptors, it also blocks bitter ones — the same bitter taste receptors that cyclamate activates.
Taste buds at the tip of the tongue, whose medical term is «fungiform papillae,»
contain sweet taste receptors, and past studies show that people with Type 2 diabetes have impaired sweet taste.
«We believe that the complimentary roles of the bitter and
sweet taste receptors in these SCCs keeps upper airway colonizing bacteria at optimal levels during periods of relative health,» Cohen says.
To study the role
of sweet taste receptors, Cohen and lead study author Robert J. Lee, PhD, a post doctoral researcher in his lab, partnered with colleagues from the Children's Hospital of Philadelphia and the Monell Chemical Senses Center to analyze cultures and tissue samples from the upper respiratory tract of patients who were undergoing sinonasal surgery for a variety of conditions.
This study, published online ahead of print in the Journal of Clinical Investigation, suggests that
sweet taste receptors expressed on SCCs in the upper airway sense bacterial overgrowth and, in turn, control the release of AMPs.
Masuda K, Koizumi A, Nakajima K, Tanaka T, Abe K, Misaka T, Ishiguro M. Characterization of the modes of binding between
human sweet taste receptor and low - molecular - weight sweet compounds.
You pop one in your mouth, activating
the sweet taste receptors on your taste buds, which then sends a signal to your cerebral cortex.
«But as the bacteria multiply, they consume more glucose, removing
the sweet taste receptor «brake» and allowing for release of AMPs by the bitter taste receptors.»
The team also found that compounds that activate
the sweet taste receptor (T1R2 / 3) suppressed the release of the AMPs produced by bitter taste receptors, indicating that these receptors have complimentary roles in regulating the innate immune pathway.
Because prior studies have shown that hyperglycemic patients also exhibit elevated nasal glucose levels, it is likely that
the sweet taste receptor function we demonstrate here may also contribute to the predisposition of diabetic patients to airway infections.»
This inability reflects damage to an underlying gene for
the sweet taste receptor.
The researchers then increased the challenge by creating a follow - up experiment in which they were given a compound that neutralized
their sweet taste receptors.