Sentences with phrase «switch in gene expression»

This models depicts the ES cell as a highly plastic but nevertheless discrete and stable cellular entity, one that in turn gives rise through a massive switch in gene expression to discrete progenitor populations with more limited developmental potential.

Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type.

Not exact matches

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

These epigenetic switches and markers in turn help switch on or off the expression of particular genes.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

What we were surprised to find out was that the real differences we could detect in terms of when we did the swap experiments to say which yeast could outperform the other — what we learned was that the GAL1 gene, that the part [of] that, the DNA sequence is outside of the GAL1 gene, it acts as a switch to turn up or turn down GAL1 expression, that had evolved considerably from the ancestral situation; and same for the GAL3.And then what had happened was that each function had been optimized, that GAL3 had sort have been tuned to be sort of a loosely regulated kind of available anytime sensor of galactose and GAL1 had evolved to be an incredibly tightly regulated, in fact, it's the most tightly regulated gene you know of in yeast.

In DIPG, this «on» switch for gene expression replaces methylation, or a protective «off» switch for cancer - causing genes.

The light - activated genetic switch could be used to turn genes on and off in gene therapies; to turn off gene expression in future cancer therapies; and to help track and understand gene function in specific locations in the human body.

The study is based on epigenetics — a scientific field that investigates gene expression in DNA by switching genes on and off.

They then asked why biglycan expression was increased in the endothelial cells, and found that the promoter region of the gene was de-methylated, meaning the gene was switched on.

Previous studies have shown a physiologic role for vitamin D in liver function, but «it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis,» says lead author Ning Ding, a research associate in the Gene Expression Laboratory.

HNF - 4α controls gene expression in the liver and pancreas, switching genes on or off as needed.

This has led to the analysis of single cell gene expression - ie which genes are switched on in a cell.

In collaboration with Margarita Salas (CBM - CSIC), in bacteriophage φ29 we examine the transcriptional regulator p4 that functions as a switch between early and late gene expression during the infection cyclIn collaboration with Margarita Salas (CBM - CSIC), in bacteriophage φ29 we examine the transcriptional regulator p4 that functions as a switch between early and late gene expression during the infection cyclin bacteriophage φ29 we examine the transcriptional regulator p4 that functions as a switch between early and late gene expression during the infection cycle.

But by placing the gene under the control of a «promoter» — an on - off switch for gene expression — from a gene (SM22a) that is expressed only in smooth muscle cells, Dr. Parmacek's team found that no matter which types of cells were infected, the gene was only «turned on» in smooth muscle cells.

These proteins work in concert with «switch» proteins such as TBX5 and GATA4 to amplify their effect on gene expression.

In young animals, immunological activation drives a conserved transcriptomic switch, resulting in tightly controlled gene expression characterized by a strong up - regulation of a core activation program, coupled with a decrease in cell - to - cell variabilitIn young animals, immunological activation drives a conserved transcriptomic switch, resulting in tightly controlled gene expression characterized by a strong up - regulation of a core activation program, coupled with a decrease in cell - to - cell variabilitin tightly controlled gene expression characterized by a strong up - regulation of a core activation program, coupled with a decrease in cell - to - cell variabilitin cell - to - cell variability.

Oct - 4 is most consistently expressed of the pluripotency genes that we have studied, and it is switched off only in populations that have lost other measurable features of pluripotency, such as stem cell surface marker expression and the capacity for self - renewal.

In the epigenome, the right lifestyle choices trigger healthy gene expression — the healthy genes get switched on, the unhealthy ones get switched off.