Sentences with phrase «switching on genes»

The science suggests that by creating muscular tension you are switching on the genes responsible for synthesising new muscle and slowing the breakdown of existing muscle.

UNSW Australia scientists have discovered a link between autism and genetic changes in some segments of DNA that are responsible for switching on genes in the brain.

They found a mechanism explaining how, in the case of pathological cardiac hypertrophy, cardiomyocytes lose their adult cellular state and regress back towards their fetal form, switching on genes that were originally expressed as the heart develops in the embryo and usually permanently switched off after birth.

Adding seven transcription factors — proteins that switch on genes — the team then converted the IPSCs into immature HSC - like cells.

These compounds, in turn, switch on the genes that enable the bacteria to colonize the gut wall and to exude their toxin.

The researchers engineered a strain in which a Synechococcus gene normally turned on during photosynthesis signals its activity by switching on the gene for luciferase, an enzyme from another bacterium that drives a light - emitting chemical reaction.

One group showed how enhancers maintain the right level of sensitivity to other signals, so that they switch on genes only at the right times and places.

Developers then used genetic control elements derived from pathogenic plant viruses such as the cauliflower mosaic virus to switch on the genes.

Light played a key role in the experiment because it allowed the researchers to switch on genes that they had added to the yeast cells.

THE gene - editing technique CRISPR has been used in the lab to switch on a gene in human brain cells whose dormancy is behind a learning disability.

Both men and women were less likely to survive if their tumour cells had switched on the genes associated with consuming sugar, or glycolysis.

However, in the absence of VHL, HIF - 1 is active even when oxygen is plentiful and switches on genes that help a cell take up more glucose.

When BMP turns ES cells into muscle it activates a protein called Smad1, a DNA - binding protein that, in opposition to Nanog, switches on genes responsible for muscle cell fate.

This seemingly small amounts of junk can also switch on genes that trigger cancer, heart disease, Alzheimer's, obesity, and other common, preventable conditions.

In fact, a single meal or snack of sugar or refined carbohydrate can not only turn off fat - burning and significantly disturb hormones, but also switch on the genes that cause disease.

Other researchers postulate that the muscle volumizing effect of creatine might switch on a gene responsible for IGF - 1 production.

Discover how to switch on the genes that create health and switch off those that create disease.

Not exact matches

Another process called epigenetics that switches genes on and off may explain why ho - mose - xuality runs in families.

Rice and his colleagues focused on epi - marks, which are molecular changes that act like temporary «switches» to turn genes on and off.

Our gee show that micro changes in our epigenetics can turn on and off genes or have them exhibit themselves in different ways and with enough flipping of the micro switches you can get some pretty impressive macro changes in relatively short periods of time.

Rather than jamming the operon, the relevant genes were copied and placed within the reach of a genetic switch which turned them on.

How the appropriate genes are switched on in appropriate places remains a problem.

However, different genes are switched on in different environments.

Apparently broccoli contains potent nutrients which have the ability to switch «on» genes that prevent cancer development, and switch «off» other ones that help it spread.

Using gene - sequencing technology, researchers established that the precise segment of the pup's DNA «switched on» by the act of grooming was the part that controlled the future function of the hippocampus, which processes stress hormones.

They discovered an orchestrated switching on and off of various genes as the mammary gland transitions from secreting small amounts of immunity - boosting colostrum in the first days after giving birth to the copious production of milk in mature lactation.

They analyzed the results to identify where the DNA had decorations called methylation — molecules attached that switch the gene on or off.

Epigenetic tags help tell genes — stretches of DNA that act as biological instruction manuals — when to switch «on» and «off,» ultimately determining cell type and function.

In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genome.

Understanding these epigenetic changes provides a possibility to switch the genes back on, helping the body stop the aggressive tumors from forming.

Nathaniel Hoyle of the MRC Laboratory of Molecular Biology in Cambridge, UK, and his colleagues have discovered that genes in a type of skin cell switch on and off during day - night cycles.

«Regulatory RNA modules are attractive for applications in synthetic biology, because they detect signals from the environment directly and instantly switch the subsequent genes on or off,» explains Johanna Roßmanith.

Tsai's group manipulated the gene for the protein p25, which has been implicated in several neurodegenerative diseases, so that it could be easily switched on and off.

«It's a master switch that turns on hundreds of genes necessary to build the powerhouse machinery of the cell.»

Within individual SCN cells, specialized clock genes are switched on and off by the proteins they encode in a feedback loop that has a 24 - hour rhythm.

The same seems to be true of the gene switches that turn on cancer cells.

Biologists are studying whether genes could be switched on and off in plants depending on climatic conditions

The key insight for building such drugs came to Tim Tully, founder and chief science officer of Helicon, when his team at Cold Spring Harbor Laboratory on Long Island stumbled upon the molecular switch: a gene called CREB, which is involved in converting short - term memories into long - term ones.

Using this technique, the team first identified millions of short fragments of RNA located at the start of genes — at the so - called «5 [prime]» end, where genes are switched on.

These epigenetic switches and markers in turn help switch on or off the expression of particular genes.

CBX2 has aroused interest as a possible master switch for maleness because tests in human cells suggest that mutations in it can shut off a gene on the Y chromosome critical for male sexual development.

The team concludes that the acetyl cap acts as an «on» switch for the crucial genes.

They noted that Tregs generally had high levels of a protein called Helios, a transcription factor that helps switch genes on and off.

More recently, it has become clear that slight variations in the regulatory sequences that determine when a gene is switched on,...

«The IMM teams showed clearly that the gene was switched on only in hypoxic regions,» says Sue Kingsman, the research director of Oxford BioMedica.

But pairs of so - called imprinted genes have just one copy «switched on».

«By switching certain genes on and off, prions could help bacteria survive environmental stresses rendering them less vulnerable to drugs, chemicals and other environmental assaults,» says investigator Ann Hochschild, professor of microbiology and immunobiology at HMS.

The new gene permanently switched on a set of genes normally affected by insulin and involved in the immune system.

Nadeau stumbled upon one study, in mice, describing how environmental factors can tag Foxp3 with chemical markers that tell T - cell precursors to switch the gene on or off.

To determine the effect of mutations that reduce TET2 function in abnormal stem cells, the research team genetically engineered mice such that the scientists could switch the TET2 gene on or off.