Borrelia burgdorferi has been found to have 16 protein structures that can cross react with thyroid proteins (5 proteins that cross-react with the TSH receptor antibodies, 2 that crossreact with Thyroglobulin antibodies, and 3 that crossreact with thyroid peroxidase antibodies (TPO antibodies), and 6 with the sodium
iodide symporter).
There is a good chance with Thyroid problems that you are Iodine deficient and / or you have problems with the
Iodine symporters which uptake Iodine into the areas where its needed.
Isolate 1 from Mouse 1 on Day 28 had a mutation in the lactose / melibiose: H
+ symporter, lacY (F27S), which is a missense mutation in the first transmembrane region (Guan et al, 2002).
Cigarette smoke contains thiocyanate, a less effective competitive sodium / iodine
symporter inhibitor than perchlorate.
Dr. David Brownstein (see below) discusses the sodium -
iodide symporter but doesn't mention pendren.
One family of iodide transporters is called the sodium - iodide
symporter, and the other is called pendren.
A second set of cellular level events involves uptake of iodine into thyroid cells by a protein referred to as the sodium - iodide
symporter (and abbreviated as «NIS,» where the «N» comes from «Na,» which is the scientific abbreviation for the element sodium).