Sentences with phrase «syn fibrils»

The cell culture experiments showed that MAbs prevented the uptake of misfolded α - syn fibrils by neurons and sharply reduced the recruitment of natural α - syn into new Lewy body aggregates.

This was accomplished using synthetically created α - syn fibrils that allowed them to observe how Parkinson's pathology developed and spread in a mouse and in neurons in a dish.

Not exact matches

They discovered that when α - synuclein fibrils are broken down, it often creates a smaller protein clump, which they named pα - syn * (pronounced «P - alpha - syn - star»).

For prevention studies, they injected mouse α - syn synthetic preformed fibrils into wild - type, normal mice, as a control, and then immediately treated the mice with Syn303, one of the MAbs used (or IgG, another type of common antibody, for the control mice).

They found that abnormal clumps of α - Syn formed by small fibrils act as «seeds» that induce normal α - Syn molecules to misfold and form aggregates.