In other words, it would take 10 million times as much BDNF to get as much new
synapse formation as Dihexa.
Not exact matches
«Given that abnormal
synapse formation causes various neurodevelopmental diseases such
as autism spectrum disorders and epilepsy, understanding activity - dependent mechanisms of initial
synapse formation will be important for developing new therapeutic strategies for these conditions,» explained Dr. Kwon.
In summary, our results demonstrate that PKN1 functions
as a developmentally active gatekeeper of AKT activity, thereby fine - tuning axonal outgrowth and presynaptic differentiation of Cgcs and subsequently the correct PF - PC
synapse formation.
Indeed, the rapid remodeling of the axon during local morphogenetic events such
as axon elongation, branch
formation and elimination and
synapse consolidation has an important energetic toll.
The processes for early brain development — neuronal migration,
synapse formation, and pruning — are responsive to and directed by environment
as well
as genetics.