Sentences with phrase «synapse loss in»

Beth Stevens, PhD Assistant Professor FM Kirby Neurobiology Center Boston Children's Hospital Harvard Medical School Immune Mechanisms of Synapse Loss in Health and Disease

We will use a glaucoma model to study whether the gene Sarm1 plays a role in glaucoma - induced axon death and synapse loss in the retina and brain.

Stevens and her team suspected that the mechanisms involved in such pruning might be aberrantly turned back on — hijacked, so to speak — to contribute to synapse loss in Alzheimer's.

«So we wanted to know: Could [such proteins] be contributing to synapse loss in these models?»

Not exact matches

-- discovered that C1q appears to be involved in synapse loss linked to glaucoma.

Hence, understanding how synaptic pruning occurs may shed light on neurodevelopmental disorders and on neurodegenerative diseases in which a synaptic pruning gone awry may contribute to pathological synapse loss.»

C1q also plays a positive role in the brain by clearing out dead cells and helping target harmful materials, so learning how to manipulate its presence to prevent debilitating synapse loss while maintaining its normal functions will require further research.

In the first group extensive synapse loss occurred in the hippocampus — loss that did not occur in the mice in which C1q had been inhibiteIn the first group extensive synapse loss occurred in the hippocampus — loss that did not occur in the mice in which C1q had been inhibitein the hippocampus — loss that did not occur in the mice in which C1q had been inhibitein the mice in which C1q had been inhibitein which C1q had been inhibited.

The study also shows that a mutation in otoferlin weakens the binding between the protein and a calcium synapse in the ear, and deficiencies in that interaction might be at the root of hearing loss related to otoferlin.

In the brain, a synapse (orange) is seen being wrapped around and attacked by immune cells called microglia (green), leading to synapse loss.

Remarkably, they found that anti-IFNAR did seem to have neuro - protective effects in mice with lupus, preventing synapse loss when compared with mice who were not given the drug.

Temporal changes in synaptic proteins in hippocampal slices indicated acute synaptic loss, followed by synapse formation and maintenance phases.

Scientists are discovering that age - related changes in the brain such as atrophy, synapse loss and free radicals may contribute to AD, as does genetics.

Building on her work in characterizing microglial subpopulations, she proposes to decipher the precise anatomical location and proximity of microglia most likely to drive neurodegeneration and synapse loss.