Sentences with phrase «synapse scaffolding protein»

Haploinsufficiency of SHANK3, encoding the synapse scaffolding protein SHANK3, leads to a highly penetrant form of autism spectrum disorder.

Not exact matches

Whereas the team's model proved that the presence of more scaffolding proteins available at the far downstream end of the neuron (and into the synapse) to AMPA receptors increased during LTP, they found the opposite condition for LDP.

Bressloff, along with mathematical biologist Berton Earnshaw, conceived of the dendritic spine — the mushroom shape at the downstream end of the neuron — as a two - compartment box: On the far downstream end, essentially in the synapse, scaffolding proteins suspend AMPA receptors so they can bind glutamate signals coming from the upstream neuron.

The other family is comprised of a family of scaffolding proteins that bind to the auxiliary subunits and thereby anchor the receptors at the synapse.