Sentences with phrase «synaptic activity»

In this sense, LPA could be a key mediator in these cases of modulation of synaptic activity in learning and memory processes, and this explains the relevance of the work we have carried out,» highlights the professor from the UCA.

The simultaneous EEG and fMRI recordings allowed us to explore how theta power fluctuations driven by the movie correlate with local synaptic activity in auditory cortex, as indexed by the BOLD signal (Magri et al., 2012; see Materials and Methods).

An international team led by Ludwig - Maximilians - Universitaet (LMU) in Munich biochemist Professor Michael Kiebler has now demonstrated that a key factor involved in this transport binds specifically to regions of its mRNA cargo that lack protein - coding information, and that release of the RNAs to enable protein synthesis is dependent on synaptic activity.

The existence of this enzyme may account for the increased amount of adenosine 3», 5» monophosphate associated with synaptic activity in the ganglion.

In what reviewers described as a «technological tour de force,» John R. Cirrito and David M. Holtzman at Washington University School of Medicine traced production of the destructive Alzheimer protein, known as amyloid - beta, to the junctions between neurons called synapses and directly linked synaptic activity to amyloid - beta increases.

In the late 1990s Goadsby and his colleagues linked cluster headaches to heightened synaptic activity falling in or near the hypothalamus, a brain region that mediates hunger, thirst, sleep, sex drive and more.

Decreased synaptic activity would show that sleep pruned unnecessary memory connections, whereas memory consolidation would have a different pattern.

Impaired synaptic activity and synapse loss have been reported in Alzheimer's disease, and synapse loss has been shown to correlate with the severity of memory impairment.

«This work shows that dendritic spines, which are sub-micrometer compartments within individual neurons, are the prime candidates for the initial tag of transient, millisecond synaptic activity that eventually orchestrates memory traces in the brain lasting tens of years,» said Shahid Khan, senior scientist at the Molecular Biology Consortium at Lawrence Berkeley National Laboratory and a co-author on the PNAS paper.

Hence, synaptic activity stimulates the docking of the mRNA to specific synapses, and its protein product marks «learning» synapses.

«Because of the self - sustaining nature of the prion - like state, this creates a local and self - sustaining translation activation of Orb2 - target mRNA, which maintains the changed state of synaptic activity over time,» says Si.

They then directly linked high synaptic activity to amyloid - beta increases.

In our present study, some preliminary evidence in favor of a primary impairment of auditory integration may come from the observation that abnormal synaptic activity levels (fMRI) and oscillation anomalies co-occurred in auditory cortex, but were dissociated in visual regions.

While at Montreal's McGill University, Haghighi had identified TOR as a critical player in balancing synaptic activity.

Dampening of synaptic activity occurred within three hours of removing nutrients from the larval food.

These animals were slower, with their brains showing synaptic activity decline.

In fact, overactive synaptic activity has been associated with diseases like Parkinson's, Alzheimer's, and other degenerative diseases.

«Our second surprising discovery is that this transport process is dependent on synaptic activity,» says Kiebler: The intron - containing mRNA is transported from one synapse to the next — but will only be released for translation in the vicinity of synapses that are momentarily active.

What they discovered was an unprecedented degradation of synaptic activity.

That is to say, we wish to see if LPA acts as a messenger produced by the neuron that regulates the synaptic activity that reaches it or if, to the contrary, is produced by the synapse and acts on the neuron.»

«We might have some real insight into the advantages of dampening of synaptic activity that is caused by fasting,» said Haghighi, for example, how fasting can be beneficial for epileptic patients, who can experience reduced seizures when restricting calories.

An international team led by LMU biochemist Professor Michael Kiebler has now demonstrated that a key factor involved in this transport binds specifically to regions of its mRNA cargo that lack protein - coding information, and that release of the RNAs to enable protein synthesis is dependent on synaptic activity.

According to their paper, the cellular stress and lack of nutrition catalyzed by fasting blocks the synaptic activity of neurons that normally occurs in the brain, which essentially means that the brain slows down.