''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the
cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (
synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular
matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).