Dr. Shelanski and his team hypothesized that aberrant activation of caspase - 2 may cause
synaptic changes in Alzheimer's disease.
The neuronal coverings that
mediate synaptic changes are involved in everything from memory to psychiatric disorders, affecting autism, Alzheimer's, and addiction.
«Machinery in the presynaptic terminal can be modified in a very acute manner to drive certain forms of plasticity, which could be really important not only in development, but also in more mature states
where synaptic changes can occur during behavioral processes like learning and memory,» Cho says.
The hippocampus is critical for episodic memory, and
synaptic changes induced by long - term potentiation (LTP) are thought to underlie memory formation.
Since 2011, as an associate professor at Stanford University, I have led a team focused
on synaptic changes occurring during normal and pathological behaviors (sleep, fragile X syndrome, ASD) as well as eye / brain neuronal regeneration.
Bock and colleagues [131]
found synaptic changes in the prefrontal cortex of rat pups exposed to 1 - hour - long separations from their mother.
These changes were region - specific, depended on timing of the separations during the first weeks of the pups» life, and they also found a possible link
between synaptic changes and endocrine function.
Her thesis was entitled «
Synaptic changes in the medial prefrontal cortex in susceptibility and resilience to stress.»