Sentences with phrase «synaptic losses with»

Not exact matches

It also revealed synaptic loss in three patients with epilepsy compared to healthy individuals.

According to Riken, the finding suggests that impaired retrieval of memories, rather than poor storage or encoding, may be behind the hallmark memory loss associated with early Alzheimer's disease, and points to the synaptic connectivity between memory cells as being crucial for the retrieval of memories.

Pathological hallmarks of AD, including plaques and loss of synaptic markers, are readily apparent at nine months of age in huAPP / PS1 mice along with clear deficits in spatial memory when compared to wild type controls [7, 10, 11, 31].

mThy1 - AS mice administered only control IgG1 suffered dendritic atrophy (as suggested by reduced staining with MAP2) and synaptic loss (evaluated with postsynaptic density - 95 (PSD - 95) and synaptophysin) across several regions of the brain, but this neurodegenerative damage was substantially prevented in mice administered 1H7, 5C1, or 9E4.

The rise in C3 protein level correlated with decreases in synaptic puncta and synaptophysin densities and synaptic protein, neuron loss, and reduced synaptic plasticity.

We have previously shown ex-vivo its beneficial effect on synaptic transmission and plasticity in a mouse model of the OPHN1 loss of function.Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1 - / y However, deficits in working and spatial memories are partially or not rescued by the treatment.

Her research interest is in neurodegenerative disease, specifically in the synaptic loss associated with Alzheimer's disease, and mechanisms of learning, memory, and consciousness.