MIT neuroscientists, led by Richard Cho, explain the mechanisms for
synaptic strengthening in a 2015 article, also published in Neuron.
By observing these natural stimuli, professor Holtmaat's team was able to demonstrate that sensory stimulus alone can generate long - term
synaptic strengthening without the neuron discharging either an induced or natural electrical pulse.
Learning and memory are governed by a mechanism of sustainable
synaptic strengthening.
A potential bridge is a process called long - term potentiation (LTP), a type of
synaptic strengthening that has been scrutinized in slices of rodent hippocampus and is widely considered a likely physiological basis for memory.
Not exact matches
When new information needs processing, the nerve cells can develop new
synaptic contacts with their neighbouring cells or
strengthen existing synapses.
The tiny electrical currents tDCS uses — generally one to two milliamps — can not actually trigger the chemical impulse that crosses a synapse, but some researchers believe tDCS
strengthens synaptic connections to make learning more efficient.
In a developing fetus, she surmised, those phone calls would reach groups of nerve cells in the LGN; as their
synaptic connections with the retinal neurons
strengthened, the LGN neurons would begin forming «area codes» of their own.
It occurs when one neuron fires closely after another, which
strengthens their
synaptic connection and makes it slightly more likely the first will trigger the second in the future.
For instance, every time we learn something, the new information is transformed into memory through
synaptic plasticity, a process in which synapses are
strengthened and become more responsive to different stimuli or environmental cues.
It manifests itself in two forms: as long - term potentiation, LTP, a
strengthening of
synaptic efficacy, and as long - term depression, LTD, a weakening of
synaptic efficacy.
«The appropriate balance of synapses
strengthening and weakening, collectively termed
synaptic plasticity, is critical for appropriate brain function.
As professor Holtmaat explains: «It is possible that sensory stimulation, when combined with another activity (motor activity, for example), works better for
strengthening synaptic connections.»
What develops the brain is stimulation — the process of
synaptic architecture depends on stimuli — it
strengthens the connections needed and prunes those not needed.
NMDA receptors are known to be involved in weakening or
strengthening synapses in neural connections, changes that are called
synaptic plasticity, and in memory formation.
Previous work had shown that spines grow when neurons undergo long - term potentiation, a persistent
strengthening of
synaptic connectivity that happens naturally in the brain but can also be artificially induced through stimulation.
The findings offer support for Tonegawa's new hypothesis that the
strengthening of
synaptic connections, while necessary for a memory to be initially encoded, is not necessary for its subsequent long - term storage.
When the researchers modeled the effects in mice, they found it
strengthened the connections between neurons that make learning possible — what is known as
synaptic plasticity — by increasing the action of a cell receptor critical to forming memories.
This
strengthened the
synaptic connections without overstimulating them — thus translating learning into long - term memories.
Learning and memory have been closely linked to
strengthening of
synaptic connections between neurons (i.e.,
synaptic plasticity) within the dentate gyrus (DG)- CA3 - CA1 trisynaptic circuit of the
That process, in turn, may generate «
synaptic plasticity» allowing the junctions between nerve cells to
strengthen and weaken more easily.
On top of a healthy diet and regular exercise, mental stimulation is what it takes to
strengthen synaptic networks.
Scientists have long known that the adult brain is surprisingly plastic — we can
strengthen synaptic connections through repetition, for example, to improve our memory.
When neurons are frequently fired,
synaptic connections are
strengthened; the opposite is true for neurons that are rarely fired.