Sentences with phrase «synaptic vesicle release»

He found that these mice had selective loss of the fast Ca2 + - triggered synaptic vesicle release.

Toxins that cleave three different subunits of the vesicular fusion machinery reveal the detailed kinetics of synaptic vesicle release.

Not exact matches

Voltage-gated calcium channels can not form properly when cacophony is mutated, preventing fusion of the synaptic vesicle with the plasma membrane and neurotransmitter release.

This allows synaptic vesicles filled with neurotransmitter to fuse with the plasma membrane and release the neurotransmitters into the synaptic cleft.

Synaptic vesicles are chock - full with neurotransmitters and release them by fusing with the presynaptic plasma membrane.

We now know that each quantum, consisting of a collection of around 5000 transmitter molecules, is contained in a little round organelle in the presynaptic terminal that Sanford Palay and George Palade had earlier discovered and called the «synaptic vesicl.e» Neurotransmitter is released from these synaptic vesicles to the outside of the neuron in response to the influx of Ca2 + into the presynaptic terminal.

«Full» vesicles move toward the membrane of the nerve terminal, represented by the overall outline of the figure, where they attach and fuse into the terminal membrane, thereby releasing the transmitter into the space between neurons, the synaptic cleft.

Beginning in 1988 Scheller, then at Stanford, succeeded in characterizing several key proteins necessary for synaptic vesicle fusion with the presynaptic membrane, the prerequisite step for neurotransmitter release.

A vesicle is a container made of a lipid membrane from which a neurotransmitter is released into the synaptic cleft — the space between neurons.

The next major advance which moved this analysis from a cell physiological to a molecular level was accomplished by Scheller and Südhof who made overlapping contributions that characterized the proteins that controlled the two key steps of transmitter release: 1) They showed the mechanism by which the vesicle is mobilized to the release sites of the presynaptic terminal, where the synaptic vesicle first fuses with the membrane of the sending neuron and then leaves the cell, and 2) they also discovered how Ca2 + drives the vesicle to release its contents.

While neurotransmitters are created in the interior of the cell, they are pumped, in large quantity, into synaptic vesicles tucked into the wall of a nerve cell's so - called «terminal,» the launch pad from which chemical messages are released from the cell.

During an action potential, calcium influx into the presynaptic terminal triggers the fusion of synaptic vesicles with the plasma membrane, leading to the release of transmitter through the process of exocytosis.

«You wouldn't have time in the speed required for synaptic transmission to make the vesicles, load them up, and put them in the active zone ready to release them.

Astrocytes, triggered by e.g. purinergic receptors (Eur J Neurosci 2007), release glutamate from VGLUT containing vesicles to enhance synaptic efficacy (Nature Neurosci 2004, 2007, Neuroscience 2009a).