Sentences with phrase «synaptic vesicles in»

Chaudhry FA, Reimer RJ, Bellocchio EE, Danbolt NC, Osen KK, Edwards RH, Storm - Mathisen J (1998) The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons J Neurosci, 18 (23), 9733 - 50 PubMed 9822734

Whittaker was the scientist who first isolated synaptic vesicles in the 1960s.

Not exact matches

During synaptic vesicle fusion, the soluble N - ethylmaleimide - sensitive factor — attachment protein receptor (SNARE) protein syntaxin - 1 exhibits two conformations that both bind to Munc18 - 1: a «closed» conformation outside the SNARE complex and an «open» conformation in the SNARE complex.

We generated knockout mice lacking synaptobrevin / VAMP 2, the vesicular SNARE protein responsible for synaptic vesicle fusion in forebrain synapses, to make use of the exquisite temporal resolution of electrophysiology in measuring fusion.

Fluorescently labeled synaptic vesicles inside the axons of cultured neurons were recorded with stimulated emission depletion (STED) microscopy in a 2.5 - micrometer by 1.8 - micrometer field of view.

In addition, synapsin II suppression resulted in a selective decrease in the amounts of several synaptic vesicle - associated proteinIn addition, synapsin II suppression resulted in a selective decrease in the amounts of several synaptic vesicle - associated proteinin a selective decrease in the amounts of several synaptic vesicle - associated proteinin the amounts of several synaptic vesicle - associated proteins.

I ache to see your action potential in action To be blinded by the searing speed of your electric signal As it sparks from node to node To behold the violent beauty of vesicles fusing with your presynaptic membrane — Pouring their contents into your synaptic cleft How I wish to be your postsynaptic cell So that I may be flooded by your molecules

The structure of synaptophysin suggests that the protein may function as a channel in the synaptic vesicle membrane, with the carboxyl terminus serving as a binding site for cellular factors.

We now know that each quantum, consisting of a collection of around 5000 transmitter molecules, is contained in a little round organelle in the presynaptic terminal that Sanford Palay and George Palade had earlier discovered and called the «synaptic vesicl.e» Neurotransmitter is released from these synaptic vesicles to the outside of the neuron in response to the influx of Ca2 + into the presynaptic terminal.

During this time, we together with our long - time collaborators Reinhard Jahn and Jose Rizo, and in parallel with Richard Scheller and others, discovered the role of SNARE and SM proteins in synaptic vesicle fusion.

Beginning in 1988 Scheller, then at Stanford, succeeded in characterizing several key proteins necessary for synaptic vesicle fusion with the presynaptic membrane, the prerequisite step for neurotransmitter release.

«If you inhibit [endocytosis in the nerve terminal], then the vesicle recycling becomes slower and the supply of the vesicles is inhibited,» OIST Professor Tomoyuki Takahashi from the Cellular and Molecular Synaptic Function Unit explains.

The study involved lab - based experiments in which synthetic vesicles, modelling the synaptic vesicles found the brain, were exposed to alpha - synuclein.

«It is a sort of shepherding effect by alpha - synuclein that occurs away from the synapse itself, and controls the number of synaptic vesicles used in each transmission,» Fusco said.

To determine whether the protein in question, at the time known as BNPI, mediated the transport of glutamate into synaptic vesicles, the researchers inserted the BNPI DNA into rat cells that normally lacked BNPI protein.

Discrete Residues in the C < sub > 2 B Domain of Synaptotagmin I Independently Specify Endocytic Rate and Synaptic Vesicle Size.

Roles of BLOC - 1 and adaptor protein - 3 complexes in cargo sorting to synaptic vesicles.

While neurotransmitters are created in the interior of the cell, they are pumped, in large quantity, into synaptic vesicles tucked into the wall of a nerve cell's so - called «terminal,» the launch pad from which chemical messages are released from the cell.

In particular, he characterized the first synaptic vesicle membrane associated protein, v - SNARE or VAMP, and the first plasma membrane associated target proteins, t - SNAREs or syntaxin and SNAP - 25.

Richard Scheller has used a combination of biochemistry, molecular biology, and cell biology to identify several key synaptic vesicle and plasma membrane proteins involved in fusion of the neurotransmitter - containing vesicles with the membrane of the presynaptic terminal.

Remarkably, there was no difference in energy levels between the two, and both types of boutons had sufficient ATP to support synaptic vesicle cycling.

«You wouldn't have time in the speed required for synaptic transmission to make the vesicles, load them up, and put them in the active zone ready to release them.

In the late 1990s, he and Reinhard Jahn, now at the Max Planck Institute of Biophysical Chemistry, determined the structures of some of the key proteins and complexes involved in the process of synaptic vesicle fusioIn the late 1990s, he and Reinhard Jahn, now at the Max Planck Institute of Biophysical Chemistry, determined the structures of some of the key proteins and complexes involved in the process of synaptic vesicle fusioin the process of synaptic vesicle fusion.

The identification of proteins, VGLUT1 - 3 (Neuron 2001, PNAS 2002), that pump glutamate into synaptic vesicles allows the packaging of the transmitter to be characterised in health and disease (J Comp Neurol 2004, 2006, 2007) and modified by gene knock - out (Science 2004).