Sentences with phrase «synaptic vesicles with»

During an action potential, calcium influx into the presynaptic terminal triggers the fusion of synaptic vesicles with the plasma membrane, leading to the release of transmitter through the process of exocytosis.

Before the fusion of synaptic vesicles with the plasma membrane, a protein complex is thought to form between VAMP — an integral membrane protein of the vesicle — and two proteins associated with the plasma membrane, SNAP - 25 and syntaxin.

Voltage-gated calcium channels can not form properly when cacophony is mutated, preventing fusion of the synaptic vesicle with the plasma membrane and neurotransmitter release.

Not exact matches

Fluorescently labeled synaptic vesicles inside the axons of cultured neurons were recorded with stimulated emission depletion (STED) microscopy in a 2.5 - micrometer by 1.8 - micrometer field of view.

This allows synaptic vesicles filled with neurotransmitter to fuse with the plasma membrane and release the neurotransmitters into the synaptic cleft.

I ache to see your action potential in action To be blinded by the searing speed of your electric signal As it sparks from node to node To behold the violent beauty of vesicles fusing with your presynaptic membrane — Pouring their contents into your synaptic cleft How I wish to be your postsynaptic cell So that I may be flooded by your molecules

The structure of synaptophysin suggests that the protein may function as a channel in the synaptic vesicle membrane, with the carboxyl terminus serving as a binding site for cellular factors.

Synaptic vesicles are chock - full with neurotransmitters and release them by fusing with the presynaptic plasma membrane.

During this time, we together with our long - time collaborators Reinhard Jahn and Jose Rizo, and in parallel with Richard Scheller and others, discovered the role of SNARE and SM proteins in synaptic vesicle fusion.

Beginning in 1988 Scheller, then at Stanford, succeeded in characterizing several key proteins necessary for synaptic vesicle fusion with the presynaptic membrane, the prerequisite step for neurotransmitter release.

This was found to interfere with the same mechanism, essentially by impairing the ability of alpha - synuclein to regulate the flow of synaptic vesicles, and hence compromising the signalling between neurons.

The next major advance which moved this analysis from a cell physiological to a molecular level was accomplished by Scheller and Südhof who made overlapping contributions that characterized the proteins that controlled the two key steps of transmitter release: 1) They showed the mechanism by which the vesicle is mobilized to the release sites of the presynaptic terminal, where the synaptic vesicle first fuses with the membrane of the sending neuron and then leaves the cell, and 2) they also discovered how Ca2 + drives the vesicle to release its contents.

Channels, which allow a compound such as glutamate to move from a compartment with high concentrations to one with low concentrations, but not vice versa, can not pump as large amounts of a compound into synaptic vesicles as a transporter can.

«Without this specialized neurotransmitter recycling and endocytosis, synaptic vesicles are not recycled fast enough to keep up with nerve and muscle cell activity,» she said.

Electron microscopic studies revealed that the presynaptic terminal of the neuron transmitting the information is filled with synaptic vesicles, small organelles containing thousands of molecules of a chemical neurotransmitter.

Richard Scheller has used a combination of biochemistry, molecular biology, and cell biology to identify several key synaptic vesicle and plasma membrane proteins involved in fusion of the neurotransmitter - containing vesicles with the membrane of the presynaptic terminal.