Phenolics are perhaps the most studied class of phytochemical compounds and more and more evidence is constantly emerging that suggests the health benefits of fruits and vegetables are attributed to the additive and
synergistic interactions of these bioactive compounds.
Vitamin C+E Serum with Ferulic Acid Utilizes
synergistic interactions of Vitamin C and E with ferulic acid to provide unmatched protection on the skin's surface.
To facilitate systematic screening for
synergistic interactions of drugs, CeMM PI Stefan Kubicek and his colleagues established a collection of 308 compounds (CeMM Library of Unique Drugs, CLOUD) that effectively represent the diversity of structures and molecular targets of all FDA - approved chemical entities.
Not exact matches
The nature
of the relationship between malnutrition and infection is found in the fact that their
interaction within the body is
synergistic; that is, the effect
of the presence
of both
of them at once is greater than the sum
of the effects
of malnutrition plus the effects
of infection.
One good example
of how the
synergistic interaction between nutrients in foods works is in regards to bone health.
«By identifying the
synergistic, additive or antagonistic
interactions between CBD and other ASDs, we are gaining a better understanding
of the nature
of these
interactions.
The
interactions between these drugs could be additive, meaning the drugs work well together;
synergistic, meaning the drugs enhance each other's effects; or antagonistic, which occurs when the combination
of drugs seems to reduce overall effectiveness.
The study points to interesting possibilities
of harnessing
synergistic host - microbe
interactions to intervene early viral spread and gut inflammation and to mitigate intestinal complications associated with HIV infection.
Future research using the specific strains
of IIV isolated from infected bees will surely confirm whether a
synergistic or additive
interaction between these two pathogens results in the signs and symptoms
of CCD.
Interference with a host
of cellular functions tested and
synergistic activities with a wide range
of other drugs is best explained by direct
interaction with various DNA sequences and general interference with replication and transcription, except for some effects exerted by binding to tubulin.
During the IAB meeting, we discussed the importance
of the
synergistic interaction between research and infrastructures.
A unique component in the consortium is the
synergistic interactions between researchers
of very diverse fields, all focusing on development
of novel techniques for solar fuels.
This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked
synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism
of action, KMT2D mutations
of B - lymphoma cells promote malignant outgrowth by perturbing methylation
of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the
interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development
of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis
of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action
of chidamide and decitabine may interfere with the differentiation and / or viability
of PTCL - NOS through a PU.1 - dependent gene expression program.
The combination index (CI) curve yielded most
of the data points to the area < 1, denoting
synergistic interactions in KMT2D V5486M mutated cells.
***** Extra Vitamin E Protected Older Mice from Getting Common Type
of Pneumonia http://now.tufts.edu/news-releases/extra-vitamin-e-protected-older-mice-getting-common-type-pneumonia «-- 1,000 times fewer bacteria in their lungs» ****** These vitamins can work synergistically:
Synergistic interactions between vitamin A and vitamin E against lipid peroxidation in phosphatidylcholine liposomes.
Herbal medicine effects are achieved through
synergistic interactions amongst small amounts
of several ingredients.
It has been suggested that the effects
of CoQ10 alone on cardiovascular disease are probably only mild to moderate, but there may be a positive (
synergistic)
interaction between CoQ10 and other cardiac medications.
Some fights may need multiple attempts, but many can be won by careful use
of the environment and
synergistic interactions between your party members.
The researchers found that the composite material not only could control both NIR light and visible light, but that there was «a
synergistic interaction in the tiny region where glassy matrix meets nanocrystal that increases the potency
of the electrochromic effect,» which means that thinner coatings
of the material could pack just as much punch.
It recognizes that some elements are under the purview
of home visiting programs themselves, while others, inherent in the nature
of coordination, rest on the
interactions and
synergistic activities
of an array
of community actors.
Maslowsky and Schulenberg (2013) found support for a
synergistic interaction such that high levels
of depressive symptoms were associated with high levels
of SU, but only when conduct problems were high.
Using a school - based sample
of 521 adolescents, we tested additive and
synergistic influences
of changes in depressive symptoms and conduct problems from 6th to 9th grade using parallel process growth curve modeling with latent
interactions in the prediction
of late adolescent (12th grade) substance use impairment, while examining gender as a moderator.