Sentences with word «synthase»

Journal of Molecular Endocrinology, 2004, 33:797 - 803, «High glucose decreases intracellular glutathione concentrations and upregulates inducible nitric oxide synthase gene expression in intestinal epithelial cells»

Given the importance of ATP synthase in fueling the cell, determining the complete structure of the enzyme has been a scientific holy grail, promising to reveal secrets about the ATP machine that could lead to therapeutic target identification and advance understanding of metabolic disease and other cellular pathologies.

In particular, chemical inhibitors of glycogen synthase kinase 3 (GSK - 3) were found to elevate SMN levels by stabilizing the protein.

Kennedy, J. Auclair, K. Kendrew, S. G. Park, C. Vederas, J. C. and Hutchinson, C. R. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.

Regulation of fatty acid synthase gene transcription.

Additionally, HMB increased glycogen, ATP, and citrate synthase activity in these muscles which may have been why the HMB - supplemented rats had increased tetonic force and fatigue resistance.

One, called phytoene synthase, had been taken from daffodils.

Along with Factor 2's powerful amino acids, vitamin C and calcium work in tandem to help increase the amount of nitric oxide synthase enzyme in your body, catalyzing the NO reaction and delivering a sustained release.

Targeting intracellular human thymidylate synthase in live cells, their pilot screen identified all drugs within the library known to act on this enzyme.

We also identify expansions and unique subfamilies of Chitin synthase genes.

Two newly synthesized 5 - methyltetrahydrofolate - like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1 / S phase and apoptosis in vitro.

This study also presents the structure - based mechanisms for substrate specificities of various PHA synthases from different classes.

Further experiments revealed that modulating activity of ATP synthase with J147 changes the levels of a number of other molecules - including levels of ATP itself - and leads to healthier, more stable mitochondria throughout aging and in disease.

Symptoms of insulin resistance include decreased stimulation of muscle glycogen synthesis as well as defects in glycogen synthase activity and glucose uptake (18).

For many years, it was thought that the breadth of ceramide synthases present in cells represented redundant functions for this family of enzymes.

In earlier work, Paller's lab had discovered that depleting an enzyme called GM3 synthase made cells particularly sensitive to growth factors and led to normal wound healing despite diabetic conditions.

The cellulose in biofilms was assumed to be the same as that produced by G. xylinus, owing to the same pattern of staining with Congo red dye and the same cellulose synthase enzyme (4 — 6).

Under the new model, researchers could target disease - specific SNO synthases working downstream of NO.

Until now, most studies of rose fragrance have focused on a biosynthetic pathway that generates pleasant - smelling alcohols, known as monoterpenes, using specific enzymes called terpene synthases.

As AT's European patent application (530 978) explains, sucrose migrates to the tubers after being formed in the leaves by an enzyme called sucrose phosphate synthase, or SPS.

Four years ago several groups found that the body has two types of prostaglandin H2 synthase: an ever - ready PGHS - 1, present in nearly all cells for basic housekeeping duties, and PGHS - 2, made only as needed and just by those cells involved in inflammation and immune responses.

The first complete structure of ATP synthase provides evidence for the mechanism by which the drug oligomycin inhibits the enzyme and how disease - causing mutations disrupt the function of the molecule.

In 2000, Australian farmers for the first time planted varieties of canola with resistance to acetolactate synthase - inhibiting herbicides.

The team eliminated three of the four known starch synthases by inserting backward copies of the genes for each one into the potato genome, which, through an unknown mechanism, interferes with the translation of the nearby normal gene.

Farnesyl pyrophosphate synthase inhibitor, ibandronate, improves endothelial function in spontaneously hypertensive rats.

Tumor necrosis factor - alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells.

The lipocalin - type prostaglandin D2 synthase knockout mouse model of insulin resistance and obesity demonstrates early hypothalamic - pituitary - adrenal axis hyperactivity

Magnesium — the second stage of glutathione synthesis in the body involves the enzyme glutathione synthase.

AgmaMAX ® -(Agmatine Sulfate)- a metabolite of arginine that plays a role in the production of nitric oxide by the modulation of nitric oxide synthase which are enzymes that play a role in nitric oxide production *.

Changing the concentration of the enzyme's substrate molecule in the model produced an outcome that described how ATP synthase interacts with its microenvironment.

Through a meticulous series of experiments, Tang homed in on one nutrient, a fatty acid called myristic acid, whose abundance, it turns out, worms can «monitor» using an enzyme called acyl - CoA synthase 4 (ACS - 4).

Galactinol synthase (GolS) is an enzyme needed to produce one these important sugars called galactinol.

«We discovered a very interesting gene that's called lycopaoctaene synthase, or LOS.

When compared with normal plants, beans from the high - radiation area had three times more cysteine synthase, a protein known to protect plants by binding heavy metals.

The journal Plant Physiology recently published their study, «Tandem Amplification of a Chromosomal Segment Harboring 5 - Enolpyruvylshikimate -3-Phosphate Synthase Locus Confers Glyphosate Resistance in Kochia scoparia.»

An electron density map obtained from crystals of a subcomplex of yeast mitochondrial ATP synthase shows a ring of 10 c subunits.

Adenosine triphosphate (ATP) synthase contains a rotary motor involved in biological energy conversion.

This illustration is a model of Chl f synthase, potentially a ChlF dimer, based on the known X-ray structure of the core of the Photosystem II reaction center.

Through several biochemical studies based on crystal structure, the authors show that PHA synthase exists as a dimer and is divided into two distinct domains, the N - terminal domain (RePhaC1ND) and the C - terminal domain (RePhaC1CD).

The key to controlling which route isocitrate will take seems to lie in the enzymes surrounding all these reactions: the enzyme isocitrate dehydrogenase keeps it for the fat - metabolism and energy production cycle; the enzymes isocitrate lyase and malate synthase divert it away into biosynthetic processes in the bacterium.

But when they cross back the other way, an enzyme called ATP synthase steals energy from the flow and stores it in molecules of ATP.