After characterising the shape of one of these catalysts, the focus of his research changed to that recognised by the 2016 Nobel Prize in chemistry:
synthesising molecules with interlocking rings and knots.
«The bottom line is: if you're going to design and
synthesise molecules you'd better understand organic chemistry.»
At the moment the best approach chemists have is to design and
synthesise a molecule, bottle it and call in «noses» to assess the concoction.
Not exact matches
Now her team has finished the end of the pathway, engineering yeasts to
synthesise finished drugs from another type of precursor
molecule (Nature Chemical Biology, DOI: 10.1038 / nchembio.1613).
Christina Smolke of Stanford University in California and her colleagues have been looking at
synthesising these complex
molecules from simple sugars.
These lower the freezing point of their body fluids as winter approaches by
synthesising antifreeze
molecules and getting rid of anything that could act as a nucleation site for ice crystals to form around, such as gut contents and bacteria.
The scientists
synthesised four variants, or derivatives, of THC by attaching a light - sensitive «antenna» to the THC
molecule.
But because RNA
molecules are quick and cheap to
synthesise, the new game goes a step further.
This would allow them to
synthesise bespoke
molecules that can function as chemical sensors or be used in other applications.
However, up to now the enzymes have had to be driven using reducing equivalents — very complex
molecules which are very expensive to
synthesise.
They also imaged two flat
molecules, hexabenzocoronene and DBNP, which were
synthesised specially for the imaging.
By carefully analysing its structure, the ITbM researchers prepared compounds that were similar to KL001, thus
synthesising the first circadian shortening
molecules that target the CRY protein.
Chemists in California have identified and
synthesised a complex sugar
molecule which lies on the surface of white blood cells, and through which the cells «recognise» those blood vessels that lie near injured tissue.
«Our results have shown that as the leftover gas from a supernova begins to cool down to below 200 °C, the many heavy elements that are
synthesised can begin to harbour rich
molecules, creating a dust factory.
This method joins
molecules together in a series of steps, while keeping one end of the compound being
synthesised anchored to a polystyrene bead.
Even so, its supporters still have to provide firm evidence that larger
molecules and membranes can be
synthesised at alkaline hydrothermal vents, says David Deamer of the University of California, Santa Cruz, who is a leading proponent of the idea that life evolved in evaporating pools instead.
Here, we demonstrate that the optical gain properties of a newly
synthesised and very luminescent (absolute PL quantum yield 79 %) nanographene
molecule, namely dibenzo [hi, st] ovalene (DBOV 1) can be preserved in the solid state by simply blending the active
molecule with polystyrene (PS).
rational drug design: which involves designing and
synthesising compounds based on the known structure of a specific target
molecule.
Over the next decade, Sauvage and his group
synthesised and characterised
molecules with more complex topologies, including a doubly - interlocking catenane and molecular trefoil knot with three loops and three crossings.
Three years later, Profs. Schill and Lüttringhaus
synthesised the first
molecule with two interlocking rings, in an elegant, but lengthy, process that built each ring of the [2] catenane sequentially.