Sentences with phrase «synthetic essential gene»
«We reasoned that this retained synthetic essential gene might be required for cancer - promoting actions when the cancers lose specific tumor suppressor genes.»
https://www.sciencedaily.com/
By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).
Not exact matches
... Accessing systems... cataloging human genomic data... compiling... analyzing... detecting essential genes... learning... modeling... accessing literature... tracking pathogens... outbreaks... viral interactions... RNAi... CRISPR... learning... modeling... analyzing social networks... crypto mining... ordering synthetic biopolymers... sending... waiting...
These data identify genes that are essential for colorectal cancer cell survival as well as synthetic lethal treatment combinations using novel computational approaches.
A synthetic lethal target is a gene which is essential for optimal fitness of a cancer cell with a specific mutation.