Sentences with phrase «synthetic lethality»
Synthetic lethality refers to a concept where two genetic changes or mutations, which individually do not cause harm, become deadly when combined. It means that when two specific alterations occur together, they generate a lethal or harmful effect. This concept is often used in cancer research to discover new ways to target and treat tumors. Full definition
Series A investors include 5AM Ventures, Canaan Partners, Celgene, WuXi Healthcare Ventures, Novartis Institute of Biomedical Research, and Alexandria Real Estate Small molecule programs with focus on synthetic lethality and...
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IDEAYA is pioneering the next generation of biomarker - enabled synthetic lethality therapies for genetically defined patient populations and advancing an immuno - oncology pipeline targeting immuno - metabolism and innate immunity.
3) Unni A *, †, Lockwood WW *, †, Zejnullahu K, Lee - Lin S, Varmus H (2015) Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.
IDEAYA Biosciences, Inc., an oncology - focused biotechnology company committed to the discovery of breakthrough synthetic lethality medicines and immuno - oncology therapies, announced today the successful completion of a $ 94 million crossover Series B financing.
«IDEAYA has assembled the vision and team, and a first - in - class synthetic lethality and immuno - oncology pipeline that has the potential to demonstrate early proof - of - concept in targeted patient populations,» said Kanishka Pothula, managing director at BVF Partners.
Defective HR is an important therapeutic target in EOC as exemplified by the efficacy of platinum analogues in this disease, as well as the advent of PARP inhibitors, which exhibit synthetic lethality when applied to HR - deficient cells.
We have shown that the loss of function of the PI5P4K enzymes results in synthetic lethality with p53 loss.
Their contributions to the yeast community include physical mapping methods, synthetic lethality screen approaches for identifying cross-species candidate genes as potential cancer drug targets, and a widely used set of vectors and yeast host strains that have been instrumental in work that has led to countless discoveries in recent decades.
Synthetic Lethality Induced by a Strong Drosophila Enhancer of Expanded Polyglutamine Tract
«We are pleased to share this vision with the unique blend of crossover funds, pharmaceutical companies, and venture capital investors participating in our Series B, and look forward to advancing our position as the leading biotech with a dual focus on synthetic lethality and immuno - oncology.»
, Lee - Lin S, Varmus H (2015) Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.
«Dr. Hambleton's unique clinical background in both immuno - oncology and synthetic lethality will strengthen our organization's capabilities as we advance multiple first - in - class programs into the clinic, leveraging our clinical strategy in patient selection and combinations.»
«Synthetic lethality represents a powerful, personalized approach to treating cancer, and IDEAYA is well positioned to advance the next wave of biomarker - driven synthetic lethality therapies into the clinic,» said Thilo Schroeder, Ph.D., partner at Nextech Invest Ltd..
This is accelerating the translation of research into transformative new therapies, and we see distinct promise in both synthetic lethality and immuno - oncology as pillars of cancer treatment in the next decade and beyond,» said Yujiro S. Hata, chief executive officer of IDEAYA.
Synthetic lethality has become a therapeutic reality with the regulatory approval of PARP inhibitors in BRCA - deficient cancers.
To get around this problem, the research team employed an approach to undruggable proteins known as «synthetic lethality,» which involves discovering the other proteins upon which these pharmacologically intractable proteins crucially depend to drive cancer growth.
The team achieved this by exploiting the concept of «synthetic lethality», where a combination of two factors kills a cancer cell.
Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in...
This is called «synthetic lethality» because the drug is only letha...
Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in BRCA1 / 2 - mutated tumors.
The ImagineArray ™ is a ready - to - run platform with pre-printed experiments that can simultaneously edit or silence up to 3200 genes, which makes it ideal for straight - forward screening as well as advanced cell biology assays such as drug / gene interaction screens and synthetic lethality.
SEngine's strategy for discovering novel drug targets integrates the concept of «synthetic lethality» to tackle «undruggable» oncogenes and loss of tumor suppressor function.