Led by Dr. Peter Glazer, chair of therapeutic radiology, Mark Saltzman, chair of biomedical engineering, and Dr. Marie Egan, professor of pediatrics and of cellular and molecular physiology, the collaborative team used
synthetic molecules similar to DNA — called peptide nucleic acids, or PNAs — as well as donor DNA, to edit the genetic defect.
Led by Dr. Peter Glazer, chair of therapeutic radiology, Dr. Mark Saltzman, chair of biomedical engineering, and Dr. Marie Egan, professor of pediatrics and of cellular and molecular physiology, the collaborative team used
synthetic molecules similar to DNA — called peptide nucleic acids, or PNAs — as well as donor DNA, to edit the genetic defect.
Not exact matches
In the first of these papers, Huc and his colleagues developed a pattern of binding interactions required to enable
synthetic molecules to assume stable forms
similar to the helical backbones of proteins.
«This is a competitive arena that includes agrichemical giants who are busily working to bring
similar drought - protecting
molecules to market, so this is a landmark discovery because quinabactin is the first - in - class
synthetic molecule of its kind,» Cutler said.
The researchers created
synthetic liquid organelles by combining, in a solution, negatively - charged RNA
molecules with positively - charged short peptides — chains of amino acids
similar to, but smaller than, proteins.
Nearly identical
molecules can have quite different scents —
synthetic musk was accidentally created from a tweaking of TNT
molecules in an explosives lab — and radically different structurescan smell
similar, like the bitter almond tinge common to both marzipan and cyanide.
They then identified
synthetic peptides, based on the known structure of a
molecule similar to IL28B, that could block the receptor — the hunt will now be on for small
molecule antagonists.
Pharmaceutical companies realised this so, over time, as technology and scientific testing became more sophisticated,
synthetic drugs were manufactured with the same or
similar molecule structure to the original plant source.