Synthetic progestins refer to man-made hormones that are similar to the natural hormone progesterone. They are produced artificially and used in medications to regulate the menstrual cycle, prevent pregnancy, or treat various conditions.
Full definition
If more physicians did that, they would find that their usual estrogen dosages create estrogen levels 8 to 10 times greater than found in normal healthy people, and that progesterone levels are not raised by giving supplements of
synthetic progestin such as medroxyprogesterone acetate (MPA).
Most progesterone hormone therapy side effects occur when people
use synthetic progestin rather than natural progesterone that is biologically identical to the hormone produced in the body.
In Lorraine A. Fitzpatrick, M.D.'s August 1999 Mayo Clinic study of 176 women taking natural oral progesterone after they had
taken synthetic progestins, 34 % felt more satisfied with the natural progesterone compared to the prior progestins.
The team determined that
unlike synthetic progestins, which increase breast cancer risks, natural progesterone has the potential to slow the growth of many breast cancer tumors or even shrink them.
Significantly, progestins» appear to inhibit biosynthesis of progesterone, lowering serum levels of the hormone and aggravating conditions linked to inadequate progesterone.5
Synthetic progestins lower the «good» HDL cholesterol and reverse the benefit of estrogen on heart disease.
Women with a history of hypertension, diabetes, weight problems, varicose veins and atherosclerosis should not be on synthetic estrogen and
synthetic progestins because it will exacerbate these conditions.
This will explain the difference
between synthetic progestins and natural progesterone, which is the difference between Hormone Replacement Therapy (HRT) and Bioidentical Hormone Replacement Therapy (BHRT).
Over time, the dose of synthetic estrogen in BCPs has declined,
more synthetic progestins have been included, and regimens beyond the 21 day active / 7 day placebo have been developed and marketed.
Compelling indications also exist that differences might also be present for the risk of developing breast cancer, with recent trials indicating that the association of natural progesterone with estrogens confers less or even no risk of breast cancer as opposed to the use of
other synthetic progestins.
If you are taking synthetic estrogen, whether by itself or in combination
with synthetic progestin, a gradual step might be to at least start natural hormones along with synthetic estrogen, for a month, then wean slowly off synthetic estrogen.
Dr. Lee emphasizes to his readers that conventional HRT
contains synthetic progestins and not natural progesterone, and that there is no evidence that using natural progesterone as he recommends, increases the risk of breast cancer, and plenty of clinical evidence that it probably protects against breast cancer.
Natural, bioidentical progesterone is not the same thing
as synthetic progestin, and the information below is solely about progesterone, not progestin.
Birth control for female giraffes includes
a synthetic progestin hormone called MGA added to their feed or Depo - Provera injections.
Synthetic progestins (often mislabeled as progesterone to add to the confusion) are known to increase the risk for breast cancer as well.
How do I get off
synthetic progestins?
Synthetic estrogens and
synthetic progestins have many side effects, increased risk of cancer is one.
The National Institutes of Health stopped a study that they were doing with women on synthetic Estrogen and
synthetic Progestin.
If someone is taking
synthetic progestin, in combination with synthetic estrogen, once they have begun using natural progesterone, simply cease the use of synthetic progestin at the end of its current 12 - day cycle of use.
Not only due estrogen cause issues, but
synthetic progestins (not bio-idential progesterone) cause issues as well.
However, many of
the synthetic progestins do raise cholesterol levels, and that is probably what your doctor was referring to.
The morning - after pill is a combination of synthetic estradiol (an estrogen) and
a synthetic progestin in high doses.
Early research on contraception was done with progestereone, and research was switched to
synthetic progestins to obtain a patent and make a profit.
Recent evidence indeed shows that natural progesterone displays a favorable action on the vessels and on the brain, while this might not be true for
some synthetic progestins.
Occasionally there is a flurry of articles claiming that progesterone is not safe, but the research that these claims are based on has always been about
the synthetic progestins, not on natural progesterone.
She explained that while Anne's symptoms were no doubt partly related to her conflict over having a baby, the severity of her headaches, depression and weight gain, as well as her cervical dysplasia, had probably been caused by the high doses of estrogen she had been taking, as well as
the synthetic progestins.
(For a detailed explanation of the difference between natural progesterone and
synthetic progestins, read What Your Doctor May Not Tell You About Menopause.)
A: Progesterone is preferable to
the synthetic progestins such as Provera, because it is natural to the body and has no undesirable side effects when used as directed.
They may fear giving progesterone because of all the side effects caused by
synthetic progestins, and may not be aware that natural progesterone, unlike synthetic progestins, is remarkably free of side effects when given in normal physiologic doses.
They espouse that there is no clinical evidence to show natural progesterone is any safer than
synthetic progestins.
Martorano JT, Ahlgrimm M, Colbert T. Differentiating between natural progesterone and
synthetic progestins: clinical implications for premenstrual syndrome and perimenopause management.
YAZ or Yasmin (known as Drospirenone) is
a synthetic progestin that is typically part of birth control medications.