Sentences with word «synuclein»

Propagation and aggregation of alpha synuclein in murine models S RAMBOZ WASHINGTON A, RAYNEL S, JASON B, NICOLE C, SHEILYN N, KIMBERLY C, KIM C, KENDALL W... Abstract / Posters

We are also interested in the effect of 7B2 and proSAAS on Parkinson's disease protein aggregates, known as Lewy bodies, which are formed from synuclein protein within brain stem areas that control movement, and have recently shown that proSAAS overexpression blocks cell death in neuronal cell cultures.

«Our approach aims to protect dopamine - producing cells by preventing α - synuclein from mis - folding in the first place.»

«The technical advances enabled high - resolution visualization of the formation of pathological alpha synuclein aggregates in hippocampal neurons.»

With the engineered cells, researchers can screen new and existing drugs to see how they regulate alpha - synuclein level in patients.

In further studies, for which Proclara received support from the Michael J. Fox Foundation, NPT088 reduced levels of alpha - synuclein aggregates in an animal model of Parkinson's disease.

The virus transferred the blueprint of the human alpha - synuclein gene specifically into neurons of the midbrain, which then began producing large quantities of the foreign protein.

Stereotaxic administration of 5μg of murine pre-formed fibrils (Proteos Inc.) is sufficient to induce a progressive α synuclein pathology, reduced dopamine levels and motor deficits in murine models (Martinez, T. et al., SFN 2014).

The specific mechanisms and pathways involved in this widespread distribution of alpha - synuclein pathology remain to be fully elucidated.

When compared to the enhanced alpha - synuclein production in the familial form of the disease, the modest effect created by the A to G mutation would be sufficient over a lifetime to increase the risk of PD, according to Soldner.

Chung and Khurana used the wealth of data from the yeast alpha - synuclein toxicity model to clue them in on key cellular processes that became perturbed as patient neurons aged in the dish.

Over-phosphorylation of serine 129 is implicated in α - synuclein aggregation and pathology.

PsychoGenics has extensive experience working with both human and murine synthetic alpha synuclein fibrils in a variety of murine neurodegenerative disease models.

The researchers used a specific genetic mouse model that recapitulates motor symptoms through α - synuclein accumulation, and genetically normal mice that were not predisposed to Parkinson's disease did not develop motor symptoms after receiving fecal transplants from patients.

Scientists at the San Diego, California, conference also described their discovery that an obscure protein carried on the cell membranes of neurons and other brain cells blocks the uptake of the α - synuclein into cells.

Adding a tag called ubiquitin to the alpha synuclein prevents it sticking together into clumps (huntingtin does this too).

The protein α - synuclein plays an important role in Parkinson's and other neurodegenerative diseases.

The pre-clinical study results show that the synthesized steroid, squalamine, prevents and eliminates alpha - synuclein build - up inside neurons by unsticking the protein from the inner wall of nerve cells, where it clings and clusters into toxic clumps, researchers say.

To start, they created two ways to systematically map the footprint of alpha - synuclein within living cells.

We should also hear soon from the Novartis trial which will give us some indication as to the potential for alpha - synuclein antibodies.

Yet if you look at people who develop the clinical syndrome of dementia, especially later in life, yes, they have amyloid in the brain but they also have other pathologic entities — vascular disease; synucleinopathies [insoluble fibrils of the normally soluble protein, alpha - synuclein]; a tauopathy [which is marked by disease - inducing, insoluble tangles of another protein, tau].

The study also reveals a preferential route of alpha - synuclein transmission via the vagus nerve.

A deeper look into the mechanism by which alpha - synuclein inhibits endocytosis revealed toxic effects of the over-assembly of microtubules.

«Orally administered squalamine prevented the formation of toxic α - synuclein clumps in this complex animal, and rescued the animal from loss of mobility,» Zasloff explains.

As a continuation of our previous study sponsored by the Michael J Fox Foundation, PsychoGenics has expanded the study in WT mice as well as other murine models to assess the behavioral and pathological consequences of α synuclein propagation and aggregation.

Columbia University filed a patent application for use of alpha - synuclein peptides as biomarkers (US Patent Application No. 15/300, 713).

By studying a strain of mice bred to overexpress α - synuclein via the Thy - 1 promoter, scientists have found these mice develop many of the age - related progressive motor symptoms of PD and demonstrate changes in sleep and anxiety.

«The effects of alpha - synuclein on mitochondria are like making a perfectly good coal - fueled power plant extremely inefficient, so it not only fails to make enough electricity, but also creates too much toxic pollution,» said Dr. Greenamyre.

The latter mechanism seems to only dispatch alpha - synuclein whereas the other system can dump several neurodegenerative disease — associated proteins.

Rather than going after proteins such as amyloid beta for Alzheimer's or alpha - synuclein for Parkinson's, one researcher has set on a different approach: «I settled on the idea that perhaps we should just get rid of as many abnormally folded, nasty - looking proteins as possible,» says Karen Duff, a neuroscientist at Columbia University.

In the study, the researchers used mice that were genetically engineered to make too much alpha - synuclein which, over time, led the animals to develop deficits similar to those observed in humans with Parkinson's.

«Parkinson's disease - like sleep and motor problems observed in alpha - synuclein mutant mice.»

Whether in a yeast cell or in a neuron, alpha synuclein directly interfered with the rate of production of proteins in the cell, and the transport of proteins between cellular compartments.

To investigate, scientists at the University of California at San Diego ran supercomputer simulations using 962,757 processor hours to explore myriad possible shapes that alpha - synuclein molecules can take.

The clumps form when alpha - synuclein develops a kink in its normally spiral structure, making it «sticky,» and prone to aggregating, Liddle said.

«It's conceivable down the road that there could be ways to prevent alpha - synuclein misfolding, if you can make the diagnosis early.»

Knowing the structures of pathological forms of amyloid seeds should help to design small molecules that bind to them and stop them doing damage, says biophysicist Ronald Melki at the Paris - Saclay Institute of Neuroscience, who works on α - synuclein strains.

Over the past few years, research in animals has shown that different strains of amyloid - β and α - synuclein exist.

Alpha - synuclein lesions have also been observed within neurons of the peripheral nervous system, such as those in the gastric wall.

Amyloid - β clumps into whitish plaques, tau forms ribbons called tangles and α - synuclein creates fibrous deposits called inclusions.

For its journey from the brain to the stomach, alpha - synuclein only used the less abundant efferent vagal projections.

Alpha - synuclein occurs naturally in the nervous system, where it plays an important role in synaptic function.

«We never see any α - synuclein until 40 years of age,» says Jeffrey Kordower of Rush University Medical Center in Chicago.

They had damaged the protein α - synuclein at several points in such a way as is normally the case in an aged cell.

However, up to now, it was not known what α - synuclein looks like inside a healthy cell.