Sentences with phrase «synuclein accumulation»
Deficiency of ATP13A2 leads to lysosomal dysfunction, α - synuclein accumulation, and neurotoxicity.
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though the exact cause of Parkinson's is unknown, evidence points to an accumulation of alpha - synuclein, which has been found to be common to all people with the disorder.
The disease is caused by the accumulation of abnormally shaped α - synuclein proteins in neurons, leading to particularly toxic effects in dopamine - releasing cells located in brain regions that control movement.
The pathological hallmark of this disease is the accumulation of alpha - synuclein, which in turn leads to cell death and consequently to problems in neurotransmission.
Until now, scientists haven't thought this build - up was important to the disease process because it looked different from the types of protein accumulations — such as tau, amyloid and alpha synuclein — that are clearly toxic and always found in patients with Alzheimer's, Parkinson's and some forms of dementia.
The diseased cells contain structures called Lewy bodies, accumulations of a protein called α - synuclein that are a hallmark of Parkinson's.
Lewy bodies (accumulation of abnormal alpha - synuclein A protein in the human brain that is associated with the development of Parkinson's.
16: Games D, Seubert P, Rockenstein E, Patrick C, Trejo M, Ubhi K, Ettle B, Ghassemiam M, Barbour R, Schenk D, Nuber S, Masliah E. Axonopathy in an α - synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C - terminal - truncated α - synuclein.
Whereas PD motor symptoms are driven by loss of dopamine - producing neurons, many of the nonmotor symptoms are instead linked to the accumulation of Lewy bodies and other malformed clumps and fibrils of the protein alpha - synuclein (AS) inside and between neurons.
PD is characterized by the progressive degeneration of midbrain dopaminergic (mDA) neurons, and the accumulation of neuronal inclusions of aggregated α - synuclein [2].
Past research has shown that Parkinson's patients with LRRK2 mutations often show an abnormal accumulation of alpha - synuclein as well.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine - producing neurons in the substantia nigra pars compacta (SNpc) and an accumulation of α - synuclein (α - syn) protein.
BHB inhibited the accumulation of the protein alpha - synuclein in NL5901 nematodes.