Sentences with phrase «synuclein aggregation»
The neuropathological semiquantitative score for alpha - synuclein aggregation was 4.
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7: Hashimoto M, Rockenstein E, Mante M, Mallory M, Masliah E. beta - Synuclein inhibits alpha - synuclein aggregation: a possible role as an anti-parkinsonian factor.
Over-phosphorylation of serine 129 is implicated in α - synuclein aggregation and pathology.
Not exact matches
In regions infected by H5N1 virus, we observe activation of microglia and alpha - synuclein phosphorylation and aggregation that persists long after resolution of the infection.
NeuroPhage has accumulated extensive preclinical data on this candidate, demonstrating its efficacy across disease models of Alzheimer's and Parkinson's disease, tauopathies and other related diseases characterized by aggregation of amyloid beta, tau, and alpha - synuclein proteins.
Systematic comparison of the effects of alpha - synuclein mutations on its oligomerization and aggregation.
[15] β - synuclein was a protein of particular concern: it exhibits strong sequence homology with AS and a similar expression pattern, and yet it is not found in LB, is not amyloidogenic, and indeed appears inhibit AS aggregation and exhibit other neuroprotective actions.
Aggregation promoting C - terminal truncation of alpha - synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease - linked mutations.
27: Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S. Overexpression of the calpain - specific inhibitor calpastatin reduces human alpha - Synuclein processing, aggregation and synaptic impairment in [A30P] αSyn transgenic mice.
Propagation and aggregation of alpha synuclein in murine models S RAMBOZ WASHINGTON A, RAYNEL S, JASON B, NICOLE C, SHEILYN N, KIMBERLY C, KIM C, KENDALL W... Abstract / Posters
Propagation and aggregation of alpha synuclein in murine models K. R. WALKER, W. ARIAS, J. BERGER, N. CHIRICHELLA, B. S. NUNEZ, R. SPRINGER, K. CIRILLO, J. SANCHEZ - PADILA, G. TOMBAUGH, A. GHAVAMI, S. RAMBOZ... Abstract / Posters
Brain changes: Lewy bodies are abnormal aggregations (or clumps) of the protein alpha - synuclein.