Sentences with phrase «synuclein fibrils»
PsychoGenics has extensive experience working with both human and murine synthetic alpha synuclein fibrils in a variety of murine neurodegenerative disease models.
http://www.psychogenics.com/
Experimental studies and a growing body of evidence has emerged demonstrating that synthetic α synuclein fibrils (both human and murine) are capable of «seeding» and propagating α synuclein pathology not only in α synuclein transgenic mouse models but importantly in non-transgenic (WT) neuronal cultures and mice (Luk, K.C. et al., 2012a; Luk, K.C. et al., 2012b; Volpicelli - Daley, L.A. et al., 2014).
They discovered that when α - synuclein fibrils are broken down, it often creates a smaller protein clump, which they named pα - syn * (pronounced «P - alpha - syn - star»).
«Sometimes the nerve cells can efficiently degrade the α - synuclein fibrils, but if they get overwhelmed, the degradation may be incomplete,» she explains.
Not exact matches
In the current study, Lasmézas and her team looked at cell cultures of neurons that were induced to accumulate fibrils made of misfolded α - synuclein, mimicking Lewy bodies in patients with Parkinson's.
Yet if you look at people who develop the clinical syndrome of dementia, especially later in life, yes, they have amyloid in the brain but they also have other pathologic entities — vascular disease; synucleinopathies [insoluble fibrils of the normally soluble protein, alpha - synuclein]; a tauopathy [which is marked by disease - inducing, insoluble tangles of another protein, tau].
Whereas PD motor symptoms are driven by loss of dopamine - producing neurons, many of the nonmotor symptoms are instead linked to the accumulation of Lewy bodies and other malformed clumps and fibrils of the protein alpha - synuclein (AS) inside and between neurons.
The main component of pathological protein fibrils in Parkinson's disease is alpha - synuclein.
Stereotaxic administration of 5μg of murine pre-formed fibrils (Proteos Inc.) is sufficient to induce a progressive α synuclein pathology, reduced dopamine levels and motor deficits in murine models (Martinez, T. et al., SFN 2014).