Sentences with phrase «synuclein gene»
These markers allowed the group to narrow the suspect region of the chromosome to a 6 - million - base - pair stretch of DNA that turned out to contain a promising gene: the - synuclein gene.
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The virus transferred the blueprint of the human alpha - synuclein gene specifically into neurons of the midbrain, which then began producing large quantities of the foreign protein.
Using the CRISPR technique, the Burnett team edited the alpha - synuclein gene and inserted a luminescent tag made from proteins that causes fireflies to light up.
For example, in sporadic PD, multiple GWAS point to the alpha - synuclein gene (SNCA) as one of the strongest risk loci in patients» genomes, yet GWAS contain little information regarding the mechanism of how this gene is dysregulated in sporadic PD patients.
Not exact matches
These human genes were also protective against alpha - synuclein - induced death, suggesting that they could be worth testing as gene therapy treatments for Parkinson's disease, Lu says.
«Among them were multiple genes known to predispose individuals to Parkinson's — so we show that various genetic forms of Parkinson's are directly related to alpha - synuclein.
This analysis produced networks that mapped out how alpha - synuclein is related to other Parkinson's genes through well - defined molecular pathways.
Using cell cultures, the research team also found two ways to prevent the toxicity caused by alpha - synuclein: gene therapy that forced the neurons to make more TOM20 protein protected them from the alpha - synuclein; and a protein that was able to prevent alpha - synuclein from sticking to TOM20 prevented alpha - synuclein's harmful effects on mitochondria.
The human alpha - synuclein protein is made of 140 amino acids and is encoded by the SNCA gene.
Some of the genes have already been identified, such as parkin (ScienceNOW, 8 April 1998), which is responsible for Parkinson's type PARK2, and alpha - synuclein (ScienceNOW, 26 June 1997), which instigates type PARK1.