Sentences with phrase «synuclein into»

Not exact matches

The prime suspect is a protein molecule called alpha - synuclein, which can bunch into long, destructive fibers.

Amyloid - β clumps into whitish plaques, tau forms ribbons called tangles and α - synuclein creates fibrous deposits called inclusions.

The virus transferred the blueprint of the human alpha - synuclein gene specifically into neurons of the midbrain, which then began producing large quantities of the foreign protein.

A deeper look into the mechanism by which alpha - synuclein inhibits endocytosis revealed toxic effects of the over-assembly of microtubules.

302 No 5651 pp 1772 - 1775 «Yeast Cells Provide Insights into Alpha - Synuclein Biology and Pathology» Authors: Tiago Fleming Outeiro and Susan Lindquist Whitehead Institute for Biomedical Research, Cambridge, MA

There are now multiple immunotherapies targeting clearance of alpha - synuclein from the brain in early - stage clinical trials, and multiple trials underway or in the works on the next generation of cell replacement therapies for dopaminergic neurons, including the TRANSEURO trial; the Summit4StemCell initiative, put together by Jeanne Loring — a researcher at The Scripps Research Institute who is exceptionally engaged with turning her research into therapies; a Japanese trial to be run by Jun Takahashi of Kyoto University in Japan (cf. here and here); and a trial centered at Memorial Sloan Kettering Cancer Center headed by cell biologist Lorenz Studer.

Roche (SIX: RO, ROG; OTCQX: RHHBY) and Prothena Corporation plc (NASDAQ: PRTA), announced today that they have entered into a worldwide collaboration to develop and commercialize antibodies that target alpha - synuclein, including PRX002... which is currently in preclinical development and is expected to enter Phase 1 clinical trials in patients with Parkinson's disease in 2014.

The pre-clinical study results show that the synthesized steroid, squalamine, prevents and eliminates alpha - synuclein build - up inside neurons by unsticking the protein from the inner wall of nerve cells, where it clings and clusters into toxic clumps, researchers say.

The pre-clinical study results show that squalamine prevents and eliminates α - synuclein build up inside neurons by unsticking the protein from the inner wall of nerve cells, where it clings and builds up into toxic clumps, researchers say.

But as the research team peered even closer into the lives of these neurons, they found something intriguing: a unique interplay between mutant LRRK2 and alpha - synuclein, another protein that has long been associated with Parkinson's.

Adding a tag called ubiquitin to the alpha synuclein prevents it sticking together into clumps (huntingtin does this too).

The new study found that T cells can be tricked into thinking dopamine neurons are foreign by the buildup of damaged alpha - synuclein proteins, a key feature of Parkinson's disease.