Sentences with phrase «synuclein looks»
However, up to now, it was not known what α - synuclein looks like inside a healthy cell.
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In the current study, Lasmézas and her team looked at cell cultures of neurons that were induced to accumulate fibrils made of misfolded α - synuclein, mimicking Lewy bodies in patients with Parkinson's.
Yet if you look at people who develop the clinical syndrome of dementia, especially later in life, yes, they have amyloid in the brain but they also have other pathologic entities — vascular disease; synucleinopathies [insoluble fibrils of the normally soluble protein, alpha - synuclein]; a tauopathy [which is marked by disease - inducing, insoluble tangles of another protein, tau].
«Our present approach was to look at this long - distance transmission of alpha - synuclein from the opposite perspective, investigating the possibility that alpha - synuclein may travel from the brain to the gut.»
Until now, scientists haven't thought this build - up was important to the disease process because it looked different from the types of protein accumulations — such as tau, amyloid and alpha synuclein — that are clearly toxic and always found in patients with Alzheimer's, Parkinson's and some forms of dementia.
A deeper look into the mechanism by which alpha - synuclein inhibits endocytosis revealed toxic effects of the over-assembly of microtubules.
«When we looked closer, we found that the removal of alpha - synuclein led to an immediate drop in levels of LRRK2.