Sentences with phrase «synuclein molecules»

To investigate, scientists at the University of California at San Diego ran supercomputer simulations using 962,757 processor hours to explore myriad possible shapes that alpha - synuclein molecules can take.

Not exact matches

The prime suspect is a protein molecule called alpha - synuclein, which can bunch into long, destructive fibers.

Knowing the structures of pathological forms of amyloid seeds should help to design small molecules that bind to them and stop them doing damage, says biophysicist Ronald Melki at the Paris - Saclay Institute of Neuroscience, who works on α - synuclein strains.

To identify promising compounds, the team grew human nerve cells in the lab and tested whether more than 1100 medications, vitamins, dietary supplements, and other molecules altered their output of α - synuclein.

In this study, the researchers demonstrated in a series of in vitro experiments that squalamine, a positively charged molecule with a high affinity for negatively charged membranes, could literally «kick off» α - synuclein from negatively charged membranes, where the protein binds, preventing the formation of the toxic clumps.