Sentences with phrase «synuclein mutant»
«Parkinson's disease - like sleep and motor problems observed in alpha - synuclein mutant mice.»
https://www.sciencedaily.com/ Not exact matches
They then programmed the neurons to express Nrf2 and either mutant LRRK2 or α - synuclein.
The scientists discovered that Nrf2 worked in different ways to help remove either mutant LRRK2 or α - synuclein from the cells.
Zhang W, Dallas S, Zhang D, Guo J - P, Wilson B, Miller DS, Chen B, Zhang W, McGeer PL, Hong J - S, Zhang J. Microglial PHOX and Mac - 1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha - synuclein.
Alpha - synuclein and its disease causing mutants induce ICAM - 1 and IL - 6 in human astrocytes and astrocytoma cells.
But as the research team peered even closer into the lives of these neurons, they found something intriguing: a unique interplay between mutant LRRK2 and alpha - synuclein, another protein that has long been associated with Parkinson's.