Sentences with phrase «synuclein only»
For its journey from the brain to the stomach, alpha - synuclein only used the less abundant efferent vagal projections.
https://www.sciencedaily.com/ Not exact matches
The latter mechanism seems to only dispatch alpha - synuclein whereas the other system can dump several neurodegenerative disease — associated proteins.
«The effects of alpha - synuclein on mitochondria are like making a perfectly good coal - fueled power plant extremely inefficient, so it not only fails to make enough electricity, but also creates too much toxic pollution,» said Dr. Greenamyre.
In a screen of nearly 200,000 compounds, Tardiff and collaborators identified one chemical entity that not only reversed alpha - synuclein toxicity in yeast cells, but also partially rescued neurons in the model nematode C. elegans and in rat neurons.
Experimental studies and a growing body of evidence has emerged demonstrating that synthetic α synuclein fibrils (both human and murine) are capable of «seeding» and propagating α synuclein pathology not only in α synuclein transgenic mouse models but importantly in non-transgenic (WT) neuronal cultures and mice (Luk, K.C. et al., 2012a; Luk, K.C. et al., 2012b; Volpicelli - Daley, L.A. et al., 2014).