Sentences with phrase «synuclein strains»
Knowing the structures of pathological forms of amyloid seeds should help to design small molecules that bind to them and stop them doing damage, says biophysicist Ronald Melki at the Paris - Saclay Institute of Neuroscience, who works on α - synuclein strains.
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In the quest for an animal model of PD that mimics motor and non-motor symptoms of human PD, scientists have developed strains of mice that overexpress α - synuclein.
By studying a strain of mice bred to overexpress α - synuclein via the Thy - 1 promoter, scientists have found these mice develop many of the age - related progressive motor symptoms of PD and demonstrate changes in sleep and anxiety.