Sentences with phrase «synuclein toxicity»
Chung and Khurana used the wealth of data from the yeast alpha - synuclein toxicity model to clue them in on key cellular processes that became perturbed as patient neurons aged in the dish.
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«Identification and Rescue of α - Synuclein Toxicity in Neurons Derived from Parkinson's Disease Patients»
In a screen of nearly 200,000 compounds, Tardiff and collaborators identified one chemical entity that not only reversed alpha - synuclein toxicity in yeast cells, but also partially rescued neurons in the model nematode C. elegans and in rat neurons.
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People whose cells make too much alpha - synuclein or make a mutated form of the protein are at high risk of developing PD because of the protein's toxicity, researchers found.
Using cell cultures, the research team also found two ways to prevent the toxicity caused by alpha - synuclein: gene therapy that forced the neurons to make more TOM20 protein protected them from the alpha - synuclein; and a protein that was able to prevent alpha - synuclein from sticking to TOM20 prevented alpha - synuclein's harmful effects on mitochondria.
Her team screened 116,000 chemical compounds to reverse the toxicity of alpha - synuclein overload in yeast.
The finding, published online today in Proceedings of the National Academy of Sciences, also demonstrated that the synthesized steroid, called squalamine, reduced the toxicity of α - synuclein clumps that already existed.