«We never see any α -
synuclein until 40 years of age,» says Jeffrey Kordower of Rush University Medical Center in Chicago.
Not exact matches
Lewy bodies were described a century ago, but it was not
until 1997 that scientists discovered they were made of clumps of a misfolded protein called α -
synuclein.
Until now, scientists haven't thought this build - up was important to the disease process because it looked different from the types of protein accumulations — such as tau, amyloid and alpha
synuclein — that are clearly toxic and always found in patients with Alzheimer's, Parkinson's and some forms of dementia.
While malfunctioning alpha -
synuclein has long been recognised as a hallmark of Parkinson's Disease, its role in healthy brains was not properly understood
until now.