The latter mechanism seems to only dispatch alpha -
synuclein whereas the other system can dump several neurodegenerative disease — associated proteins.
Not exact matches
«One possible explanation is that UPDRS reflects primarily deficits arising from nigrostriatal degeneration,
whereas CSF α -
synuclein levels are influenced by the whole brain and may serve as a proxy for total brain pathology,» says Dr. Zhang.
Whereas PD motor symptoms are driven by loss of dopamine - producing neurons, many of the nonmotor symptoms are instead linked to the accumulation of Lewy bodies and other malformed clumps and fibrils of the protein alpha -
synuclein (AS) inside and between neurons.