Sentences with phrase «synuclein which»

Not exact matches

Earlier this year the company reported that patients who took PRX - 002 saw their alpha synuclein levels drop by as much as 96 %, which is a massive improvement that performed significantly better than a placebo.

Although one of the mutations has no effect, the other, which switches one nucleotide from an A to a G, slightly but significantly boosts alpha - synuclein production.

The researchers hypothesize that these chaperone proteins may assist in the proper folding of alpha synuclein, which could prevent it from forming clumps.

though the exact cause of Parkinson's is unknown, evidence points to an accumulation of alpha - synuclein, which has been found to be common to all people with the disorder.

The study, published in the October edition of the journal Neurotherapeutics, found that the drug, AT2101, which has also been studied for Gaucher disease, improved motor function, stopped inflammation in the brain and reduced levels of alpha - synuclein, a protein critically involved in Parkinson's.

«More light means an increased level of alpha - synuclein, which would be considered a diseased state.»

(To do the experiment in a blinded, unbiased manner, the Loyola researchers did not know which types of alpha - synuclein were which.)

The prime suspect is a protein molecule called alpha - synuclein, which can bunch into long, destructive fibers.

They discovered that when α - synuclein fibrils are broken down, it often creates a smaller protein clump, which they named pα - syn * (pronounced «P - alpha - syn - star»).

Last week, findings presented at the huge annual meeting of the Society for Neuroscience further buttressed the theory that spread of the rogue protein, called α - synuclein, is responsible for the progressive disease, which is marked by tremor, stiff movements, depression, and, ultimately, dementia.

They found that by attaching to a mitochondrial protein called TOM20, alpha - synuclein prevented the mitochondria from functioning optimally, which resulted in the production of less energy and more damaging cellular waste.

Yet if you look at people who develop the clinical syndrome of dementia, especially later in life, yes, they have amyloid in the brain but they also have other pathologic entities — vascular disease; synucleinopathies [insoluble fibrils of the normally soluble protein, alpha - synuclein]; a tauopathy [which is marked by disease - inducing, insoluble tangles of another protein, tau].

The pathological hallmark of this disease is the accumulation of alpha - synuclein, which in turn leads to cell death and consequently to problems in neurotransmission.

The pesticide - linked damage starts with ziram's ability to increase concentrations of a protein, called α - synuclein, which is abundant in the human brain.

Alpha - synuclein is the primary structural component of Lewy bodies, which are clumps of protein that develop inside nerve cells in Parkinson's disease and some other disorders.

Inside these cells is a protein called alpha - synuclein, which is known to go awry and lead to damaging clumps in the brains of Parkinson's patients, as well as those with Alzheimer's disease.

The virus transferred the blueprint of the human alpha - synuclein gene specifically into neurons of the midbrain, which then began producing large quantities of the foreign protein.

Some of the genes have already been identified, such as parkin (ScienceNOW, 8 April 1998), which is responsible for Parkinson's type PARK2, and alpha - synuclein (ScienceNOW, 26 June 1997), which instigates type PARK1.

A deeper look into the mechanism by which alpha - synuclein inhibits endocytosis revealed toxic effects of the over-assembly of microtubules.

«Because we have shown that mutated forms of alpha - synuclein, which are associated with early onset familial forms of Parkinson's Disease, affect this process, we also now know that this is a function that may be impaired in people who carry these mutations.»

For example, it is known that α - synuclein has a very concrete structure, which means that it is based on a blueprint that follows a specific pattern.

The study involved lab - based experiments in which synthetic vesicles, modelling the synaptic vesicles found the brain, were exposed to alpha - synuclein.

In further studies, for which Proclara received support from the Michael J. Fox Foundation, NPT088 reduced levels of alpha - synuclein aggregates in an animal model of Parkinson's disease.

Roche (SIX: RO, ROG; OTCQX: RHHBY) and Prothena Corporation plc (NASDAQ: PRTA), announced today that they have entered into a worldwide collaboration to develop and commercialize antibodies that target alpha - synuclein, including PRX002... which is currently in preclinical development and is expected to enter Phase 1 clinical trials in patients with Parkinson's disease in 2014.

In Parkinson's disease, α - synuclein, a normal protein present within the nervous system, forms toxic clumps that damage and ultimately destroy the neurons in which they form.

In contrast, T cells in patients» blood samples, which had been apparently primed to recognize alpha - synuclein from past exposure, showed a strong response to the protein fragments.

«In most cases of Parkinson's, dopamine neurons become filled with structures called Lewy bodies, which are primarily composed of a misfolded form of alpha - synuclein,» said Dr. Sulzer.

In Parkinson's disease, characterized neuropathologically by the presence of intraneuronal Lewy bodies and Lewy neuritis, the attention has been particularly focused on mis-folded and aggregated α synuclein (fibrillar α synuclein) which is a major component of both Lewy bodies and Lewy neurites.

«Our findings raise the possibility that an immunotherapy approach could be used to increase the immune system's tolerance for alpha - synuclein, which could help to ameliorate or prevent worsening symptoms in Parkinson's disease patients,» said Dr. Sette.