To start, they created two ways to systematically map the footprint of alpha -
synuclein within living cells.
Not exact matches
Fibers of the vagus nerve connect the brain to a variety of internal organs; travelling
within these fibers, human alpha -
synuclein was ultimately able to reach the gastric wall about six months after its initial midbrain expression.
Alpha -
synuclein lesions have also been observed
within neurons of the peripheral nervous system, such as those in the gastric wall.
In Parkinson's disease, α -
synuclein, a normal protein present
within the nervous system, forms toxic clumps that damage and ultimately destroy the neurons in which they form.
As these worms age, α -
synuclein builds up
within their muscle cells causing cell damage and paralysis.