Sentences with phrase «system cells attack»

What happens in Degenerative Myelopathy is the dog's own immune system cells attack the spinal cord sheath.

In both types of MS, immune system cells attack and strip away myelin, the fatty protective sheathing that insulates nerve cells.

Not exact matches

Rather than an activator of T cells, the molecule acted like a brake, stopping the immune system from its attack.

Immune oncology drugs use a mechanism to enable the immune system to «uncloak» hidden cancer cells in the body and then attack them.

The drug has an unfortunate side effect of tricking the immune system into attacking healthy cells, but the relative damage was insignificant compared to what cancer would have done to them.

This is the group of genes which act as the immune system markers on cells, protecting them from being attacked by the system's anti-bodies.

* CD4 cells are a component of the immune system attacked by HIV.

Simberg and colleagues also tried turning off the complement system — a facet of the immune system responsible for clearing microbes and damaged cells — thinking that this complement system might be attacking, transporting or otherwise accidentally pushing liposomes from blood to cells.

A group of the nation's leading cancer research scientists and their Cuban counterparts are exploring how to advance cancer therapy, diagnosis, and prevention, including the use of immunotherapy to harness the body's immune systems to attack and eliminate cancer cells.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

For unknown reasons our immune system attacks healthy cells, tissues and organs in a process called autoimmunity, which can result in diseases such as multiple sclerosis, type 1 diabetes, lupus or rheumatoid arthritis.

Previously, Derek Danahy of the University of Iowa and colleagues showed that sepsis disrupts the immune system by reducing the amount and function of memory T cells that circulate throughout the body, recognizing and attacking specific bacteria, viruses, or cancer cells.

Two groups had their immune systems altered to produce fewer macrophages, the white blood cells that attack pathogens.

We now know the virus attacks a person's T lymphocytes, a type of white blood cell that plays a central role in the immune system.

Hoxb8 is usually active in microglia, immune - system cells that clean up damaged neurons and attack pathogens in the brain.

When the dendritic cells are activated, they train T cells — their allies in the adaptive arm of the immune system — to attack cancer cells anywhere in the body, whether at the site of the original tumor or distant metastases.

Typically, when the body senses a foreign substance such as a virus or a bacterium, it sends immune cells to attack the invader while also bolstering the immune system as a whole.

It indicates to the immune system that a cell is «self,» and so not to be attacked.

When the T cells of your immune system are forced to deal over time with cancer or a chronic infection such as HIV or hepatitis C, they can develop «T cell exhaustion,» becoming less effective and losing their ability to attack and destroy the invaders of the body.

But during pregnancy, the fetus is protected from the mother's immune system by the placenta, which has specialized cells — called trophoblasts — that can burrow into the mother's body without exciting an attack by the immune system.

Pembrolizumab, which is marketed under the brand name Keytruda, works by turning off the immune system's brakes, allowing its T cells to recognize and attack cancer cells.

These cells play a key role in autoimmune disease — in which the immune system mistakenly identifies the body's own tissues as foreign and attack them.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

They also found AXIN2 in the damaged nerve cells of adults with multiple sclerosis, a disease in which the immune system attacks myelin.

Blood from people affected by the 2014 Zika outbreak in French Polynesia provides the first evidence that the virus can make the immune system attack nerve cells

Others are finding ways to boost the body's own immune system to attack cancer cells.

However, those antibodies also bind to leiomodin - 1, so the immune system - incorrectly - will attack brain cells that contain that protein, which can result in symptoms of Nodding syndrome.

There was another intriguing connection: Acinetobacter are molecular mimics of proteins found in myelin, the nerve cell coating that the immune system attacks in MS.. That suggests the bacteria might trigger immune attacks that hit myelin, too, as when soldiers who inadvertently resemble the enemy get hit by friendly fire.

Antibodies and T cells against the protein could cause the immune system to attack cells carrying it, making gene therapy ineffective.

Immunotherapy is an emerging field in the global fight against cancer, even though scientists and clinicians have been working for decades to find ways to help the body's immune system detect and attack cancerous cells.

Type 1 diabetes, which usually starts in childhood, is an autoimmune disease in which the immune system attacks the body's own beta cells.

Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.

Although Coley couldn't explain precisely why or how his toxins worked, modern immunotherapy treatments help T - cells in the immune system to recognize specific cancer cells and attack them.

The researchers speculate that the beetle's revived immune system discovers and attacks DCPV - infected cells.

Researchers are developing many different versions of CAR - T cell therapies, but the basic premise is the same: Doctors remove a patient's T cells (immune system cells that attack invaders) from a blood sample and genetically modify them to produce artificial proteins on their surfaces.

The momentum started building in 2010 when the FDA approved Provenge, a cancer vaccine that rallies male patients» immune systems to attack prostate cancer cells, allowing patients with an advanced form of the cancer to live several months longer.

The four children also had more of the types of species that are known to trigger gut inflammation, a possible prelude to type - 1 diabetes, in which the body's immune system mistakenly produces antibodies that attack and destroy the beta cells of the pancreas that normally make insulin.

A phase 3 trial of lenalidomide / dexamethasone with elotuzumab (Empliciti ™), an antibody therapy that attacks myeloma cells directly and spurs the immune system to launch an attack of its own.

The disease commonly starts in childhood and causes the body's own immune system to attack and destroy the insulin - producing cells in the pancreas, leaving the patient dependent on life - long insulin injections.

Although some cancers — particularly those that are rife with mutations like lung cancer or melanoma — create more tangible targets on the surface of cells for the immune system to recognize and attack, other malignancies such as prostate and pancreatic cancers have proved more intransigent.

T cells, along with B cells and others, comprise the adaptive arm of the immune system, the body's second line of defense which quickly attacks and «remembers» specific pathogens.

In the hunt for genetic and environmental factors responsible for allergies, a prime suspect has been interleukin - 4 (IL - 4); this immune system protein tells white blood cells to make IgE antibodies, which recognize foreign substances and set off an immune attack.

According to Dr. Cripe, the study suggests that some patients could respond to therapy even if their tumors aren't very infectable by the virus, provided their immune systems were stimulated by the viral therapy to attack the tumor cells.

This made it possible for their immune systems to produce sufficient amounts of CD8 T cells that were primed to attack and kill HIV - infected cells.

The researchers studied two types of cells called effector T cells, which activate the immune system to defend our body against different pathogens, and regulatory T cells, which help control the immune system and prevent it from attacking healthy parts of its environment.

Immune therapy for ovarian, breast and colorectal cancer — treatments that encourage the immune system to attack cancer cells as the foreign invaders they are — has so far had limited success, primarily because the immune system often can't destroy the cancer cells.

The immune system can, for example, dispatch «regulatory» cells that suppress immune attacks against self.

The known FPRs include two immune system receptors that detect chemicals given off by pathogens in the blood, helping immune cells track down and attack foreign bodies.

It is Regeneron's first drug candidate that will harness the immune system to attack cancer cells, he says.

This, she hopes, will enable «the good guys» - cells of the immune system - to specifically attack and destroy tumors.